产品名称
鞘氨醇 (d18:1), Avanti Research™ - A Croda Brand
SMILES string
OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
InChI key
WWUZIQQURGPMPG-KRWOKUGFSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860490P-10mg)
pkg of 1 × 25 mg (860490P-25mg)
pkg of 1 × 500 mg (860490P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
鞘氨醇 (d18:1) 已被用于：
- 小鼠鞘氨醇吸入研究中，以评估其在呼吸道上皮细胞中的治疗潜力
- 研究其对铜绿假单胞菌菌株的影响
- 作为液相色谱串联质谱法中的标准品，用于对表皮神经酰胺的定量
Biochem/physiol Actions
鞘氨醇（d18：1）对于包括细胞分化、生长和存活在内的生理过程至关重要。它可激活瞬态受体电位阳离子通道亚家族成员3（TRPM3）。
General description
鞘氨醇 (d18:1) 是存在于动植物中的一种鞘氨醇骨架。它具有2-氨基-1,3-二醇官能团，并且其较难从动物组织中进行提取。 鞘氨醇 (d18:1) 可由D-半乳糖通过手性方法进行合成。
Packaging
20 mL透明玻璃螺旋盖小瓶（860490P-500mg）
5 mL琥珀色玻璃螺旋盖小瓶（860490P-10mg）
5 mL琥珀色玻璃螺旋盖小瓶（860490P-25mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 4
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog
Duclos Jr RI
Chemistry and Physics of Lipids, 111(2), 111-138 (2001)
Efficient Synthesis of d-erythro-Sphingosine and d-e rythro-Azidosphingosine from d-r ibo-Phytosphingosine via a Cyclic Sulfate Intermediate
Kim S, et al.
The Journal of Organic Chemistry, 71(22), 8661-8664 (2006)
Sphingosine's role in epithelial host defense: A natural antimicrobial and novel therapeutic
Martin GE, et al.
Biochimie, 141, 91-96 (2017)
Glucosylceramide critically contributes to the host defense of cystic fibrosis lungs
Kovacic B, et al.
Cellular Physiology and Biochemistry, 41(3), 1208-1218 (2017)
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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