产品名称
Monomethyl Sphingosine (d18:1), Avanti Research™ - A Croda Brand 860495P, powder
InChI key
LUMQNHNDMLZNDJ-OVMWUVNSSA-N
SMILES string
OC[C@@](NC)([H])[C@]([H])(O)/C=C/CCCCCCCCCCCCC
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860495P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860495P
lipid type
deuterated lipids
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Monomethyl sphingosine or N-methyl-D-erythro-sphingosine is a N-methyl derivative of sphingosine
Application
Monomethyl sphingosine or N-methyl-D-erythro-sphingosine may be used as one of the substrates for sphingosine methyltransferase to test its substrate specificity in rat kidney homogenate.
Biochem/physiol Actions
Monomethyl sphingosine inhibits protein kinase C. It also modulates other protein kinases and enzymes involved in signal transduction.
Packaging
5 mL Amber Glass Screw Cap Vial (860495P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Biological Function of Gangliosides (1994)
Handbook of Neurochemistry and Molecular Neurobiology:Neural Lipids (2009)
Santosh J Sacket et al.
Acta pharmacologica Sinica, 29(10), 1227-1232 (2008-09-27)
To characterize sphingosine methyltransferase in rat tissues. By using S-adenosyl-L-(methyl-3H) methionine, enzymatic activity was measured in the rat liver and kidney homogenates. The optimum pH and reaction time for the enzyme assay were pH 7.8 and 1 h. ZnCl2 inhibited
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