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经验公式（希尔记法）:
C21H44NO2
化学文摘社编号:
分子量:
342.58
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
Trimethyl Sphingosine (d18:1), Avanti Research™ - A Croda Brand 860497P, powder
SMILES string
[S](=O)(=O)([O-])OC.[N+]([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)(C)C
InChI
1S/C21H44NO2.CH4O4S/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-21(24)20(19-23)22(2,3)4;1-5-6(2,3)4/h17-18,20-21,23-24H,5-16,19H2,1-4H3;1H3,(H,2,3,4)/q+1;/p-1/b18-17+;/t20-,21+;/m0./s1
InChI key
OJPBMRHTGOLVFX-DSQFUKAXSA-M
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860497P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860497P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Trimethyl sphingosine (d18:1) or N,N,N-trimethyl-D-erythro-sphingosine (methyl sulfate salt) is a N-methylated sphingosine derivative.
Biochem/physiol Actions
Trimethyl sphingosine (TMS) is a protein kinase C inhibitor. It also regulates other protein kinases and enzymes implicated in signal transduction. TMS lowers transendothelial migration of neutrophils. It reduces platelet agglomeration at physiologic concentrations and attenuates myocardial reperfusion injury.
Packaging
5 mL Amber Glass Screw Cap Vial (860497P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
R Knöfler et al.
Thrombosis research, 76(4), 323-332 (1994-11-15)
We investigated the influence of N,N,N-trimethylsphingosine (TMS), a potent inhibitor of protein kinase C (PKC), on whole blood aggregation and ATP release from platelets. The preincubation with TMS at 1 microM for 2 min enhanced ATP release during arachidonic acid-induced
B Campbell et al.
Cardiovascular research, 39(2), 393-400 (1998-11-03)
Ischemia followed by reperfusion in the presence of polymorphonuclear leukocytes (PMNs) results in cardiac contractile dysfunction as well as myocardial injury. These deleterious effects are due in large part to endothelial dysfunction leading to an upregulation of cell adhesion molecules
Biological Function of Gangliosides (1994)
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