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关于此项目
经验公式（希尔记法）:
C42H83NO3
化学文摘社编号:
分子量:
650.11
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C24 神经酰胺 (d18:1/24:0), Avanti Research™ - A Croda Brand
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
InChI
1S/C42H83NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h35,37,40-41,44-45H,3-34,36,38-39H2,1-2H3,(H,43,46)/b37-35+/t40-,41+/m0/s1
InChI key
ZJVVOYPTFQEGPH-AUTSUKAISA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860524P-10mg)
pkg of 1 × 5 mg (860524P-5mg)
pkg of 1 × 50 mg (860524P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
C24 神经酰胺 (d18:1/24:0) 曾被用于：
- 产生小的单层囊泡
- 作为液相色谱-质谱法中的内标物从大鼠样品中定量测定神经酰胺
- 测试其对蠕虫线粒体应激反应的影响
Biochem/physiol Actions
C24 神经酰胺诱导线粒体应激反应。在冠状动脉疾病 (CAD) 中，其水平被耗尽。然而，在阿尔茨海默病患者中观察到神经酰胺水平升高。C24 在强制降解过程中合成。介导自发性中性粒细胞死亡。
General description
C24 神经酰胺具有 24 个碳单位的长酰基链长度。
Packaging
5 mL 棕色玻璃螺旋盖小瓶 (860524P-10 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860524P-5 mg)
5 mL 棕色玻璃螺旋盖小瓶 (860524P-50 mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Ceramides and sphingomyelinases in senile plaques
Panchal M, et al.
Neurobiology of Disease, 65, 193-201 (2014)
Permeability and microstructure of model stratum corneum lipid membranes containing ceramides with long (C16) and very long (C24) acyl chains
Pullmannova P, et al.
Biophysical Chemistry, 224, 20-31 (2017)
Liposome Preparation for the Analysis of Lipid-Receptor Interaction and Efferocytosis
Voss OH, et al.
Current Protocols in Immunology, 120(1), 14-44 (2018)
Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides
Kauhanen D, et al.
Analytical and Bioanalytical Chemistry, 408(13), 3475-3483 (2016)
Grégory Seumois et al.
Journal of leukocyte biology, 81(6), 1477-1486 (2007-03-03)
Neutrophils rapidly undergo spontaneous apoptosis following their release from the bone marrow. Although central to leukocyte homeostasis, the mechanisms that regulate neutrophil apoptosis remain poorly understood. We show here that apoptosis of cultured neutrophils is preceded by a substantial increase
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