产品名称
1-O-Acyl-Ceramide, Avanti Research™ - A Croda Brand 860526P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860526P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860526P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O
InChI
1S/C53H101NO4/c1-4-7-10-13-16-19-22-25-27-30-33-36-39-42-45-48-53(57)58-49-50(51(55)46-43-40-37-34-31-28-24-21-18-15-12-9-6-3)54-52(56)47-44-41-38-35-32-29-26-23-20-17-14-11-8-5-2/h25,27,43,46,50-51,55H,4-24,26,28-42,44-45,47-49H2,1-3H3,(H,54,56)/b27-25-,
InChI key
FRBOSLBQGQIWQM-YXQBTRHCSA-N
General description
1-O-Acyl-Ceramide is an epidermal ceramide present in mouse and human epidermis. It comprises long chain fatty acids in 1-O-position and is synthesized in the endoplasmic reticulum-related sites.
Application
1-O-Acyl-Ceramide is suitable for use as a lipid standard in
- high performance thin layer chromatography (HPTLC)
- in mass and nuclear magnetic resonance spectroscopy for the quantification of lipids isolated from vernix caseosa skin cream
- in liquid chromatography-tandem mass spectrometry for the quantification of 1-O-Acyl ceramides from liver samples
Biochem/physiol Actions
1-O-Acyl-Ceramide functions in maintaining water barrier homeostasis. Deficiency of the glucosylceramide synthase enzyme leads to the accumulation of O-acylceramides. Treatment of human monoclonal antibody, REMD 2.59 leads to the accumulation of 1-O-acyl-ceramides in soleus muscle and depletion in liver.
Packaging
5 mL Amber Glass Screw Cap Vial (860526P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3