产品名称
C24 1-磷酸神经酰胺 (d18:1/24:0), Avanti Research™ - A Croda Brand 860527P, powder
InChI key
JGGZHGYBRJNAOW-FHPBFELKSA-N
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)COP([O-])(O)=O.[NH4+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860527P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860527P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
C24神经酰胺-1-磷酸盐（d18:1/24:0）或N-木质素酰神经酰胺-1-磷酸盐（铵盐）已用作标准品，可通过高效液相色谱法/串联质谱法（LC/MS2）定量分析肌肉组织样品中的神经酰胺含量。
Biochem/physiol Actions
神经酰胺-1-磷酸盐（C1P）是一种促有丝分裂剂，具有抗凋亡和促生存活性。它负调节脂多糖刺激的肿瘤坏死因子-α（TNFα）的产生。C1P还介导炎症反应并有助于吞噬作用。它被认为是激动剂刺激的鞘磷脂代谢的第二个脂质信使。
General description
神经酰胺-1-磷酸盐（C1P）是磷脂酸盐的鞘脂类似物。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860527P-1mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Szczepan Józefowski et al.
Journal of immunology (Baltimore, Md. : 1950), 185(11), 6960-6973 (2010-11-03)
LPS is a constituent of cell walls of Gram-negative bacteria that, acting through the CD14/TLR4 receptor complex, causes strong proinflammatory activation of macrophages. In murine peritoneal macrophages and J774 cells, LPS at 1-2 ng/ml induced maximal TNF-α and MIP-2 release
Lide Arana et al.
Lipids in health and disease, 9, 15-15 (2010-02-09)
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction
Antonio Gómez-Muñoz et al.
Journal of lipid research, 45(1), 99-105 (2003-10-03)
It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883-889; Gómez-Muñoz, A., L. M. Frago, L. Alvarez
V T Hinkovska-Galcheva et al.
The Journal of biological chemistry, 273(50), 33203-33209 (1998-12-05)
Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear leukocytes. Agonist-stimulated formation of ceramide-1-phosphate is now shown to occur in 32PO4-labeled neutrophils. Ceramide-1-phosphate is formed by a calcium-dependent ceramide
A Gomez-Muñoz et al.
Molecular pharmacology, 47(5), 833-839 (1995-05-01)
Ceramide and ceramide-1-phosphate are sphingolipid analogues of diacylglycerol and phosphatidate, respectively, and they are putative second messengers of agonist-stimulated sphingomyelin metabolism. The interactions of exogenous cell-permeable ceramides and ceramide-1-phosphates in modifying DNA synthesis and signal transduction were investigated in Rat-1
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