登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C24H47NO7
化学文摘社编号:
分子量:
461.63
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
Glucosyl(β) Sphingosine (d18:1), Avanti Research™ - A Croda Brand
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@](N)([H])CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O
InChI
1S/C24H47NO7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(27)18(25)17-31-24-23(30)22(29)21(28)20(16-26)32-24/h14-15,18-24,26-30H,2-13,16-17,25H2,1H3/b15-14+/t18?,19-,20-,21-,22+,23+,24-/m1/s1
InChI key
HHJTWTPUPVQKNA-SKXACSAKSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 25 mg (860535P-25mg)
pkg of 1 × 5 mg (860535P-5mg)
pkg of 1 × 50 mg (860535P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
Glucosyl(β) Sphingosine (d18:1) or D-glucosyl-β1-1′-D-erythro-sphingosine may be used:
- to screen lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) or tight junction (TJ) permeability in epithelial tissue
- as a standard for the quantification of glucosyl sphingosine in Gaucher patients using liquid chromatography electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS)
- as an internal standard for the quantification of lysoglucosylceramide in plasma for Gaucher disease using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
Biochem/physiol Actions
Glucosyl sphingosine is a potential biomarker for Gaucher′s disease. It modulates Ca2+ release in the brain microsomes.
General description
Glucosyl sphingosine is a lyso derivative of glucosylceramide (GlcCer).
Packaging
5 mL Amber Glass Screw Cap Vial (860535P-25mg)
5 mL Amber Glass Screw Cap Vial (860535P-50mg)
5 mL Amber Glass Screw Cap Vial (860535P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Arndt Rolfs et al.
PloS one, 8(11), e79732-e79732 (2013-11-28)
Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as well as analysis of chitotriosidase and
Magali Pettazzoni et al.
PloS one, 12(7), e0181700-e0181700 (2017-07-28)
The biological diagnosis of sphingolipidoses currently relies on the measurement of specific enzymatic activities and/or genetic studies. Lysosphingolipids have recently emerged as potential biomarkers of sphingolipidoses and Niemann-Pick type C in plasma. We developed a sensitive and specific method enabling
Emyr Lloyd-Evans et al.
The Journal of biological chemistry, 278(26), 23594-23599 (2003-04-24)
We recently demonstrated that elevation of intracellular glucosylceramide (GlcCer) levels results in increased functional Ca2+ stores in cultured neurons, and suggested that this may be due to modulation of ryanodine receptors (RyaRs) by GlcCer (Korkotian, E., Schwarz, A., Pelled, D.
Nick Dekker et al.
Blood, 118(16), e118-e127 (2011-08-27)
Gaucher disease, caused by a deficiency of the lysosomal enzyme glucocerebrosidase, leads to prominent glucosylceramide accumulation in lysosomes of tissue macrophages (Gaucher cells). Here we show glucosylsphingosine, the deacylated form of glucosylceramide, to be markedly increased in plasma of symptomatic
Shu-Chih Chen-Quay et al.
Journal of pharmaceutical sciences, 98(2), 606-619 (2008-06-20)
Tight junctions (TJs) play an important role in regulating paracellular drug transport. The aim of this study was to identify lipids that rapidly and reversibly alter transepithelial electrical resistance (TER) and/or TJ permeability in epithelial tissue. In this study, we
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持