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经验公式（希尔记法）:
C38H71NO13
化学文摘社编号:
分子量:
749.97
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C8 Lactosyl(β) Ceramide (d18:1/8:0), Avanti Research™ - A Croda Brand 860541P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860541P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860541P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H]([C@H]1CO)O[C@H](O2)[C@H](O)[C@@H](O)[C@H]([C@H]2CO)O
InChI
1S/C38H71NO13/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-27(42)26(39-30(43)22-20-17-8-6-4-2)25-49-37-35(48)33(46)36(29(24-41)51-37)52-38-34(47)32(45)31(44)28(23-40)50-38/h19,21,26-29,31-38,40-42,44-48H,3-18,20,22-25H2,1-2H3,(H,39,43)/b21-19+/t26-,27+,28?,29?,31-,32?,33?,34?,35?,36+,37+,38-/m0/s1
InChI key
JUCWRRXMPGRQOG-WKSBFREFSA-N
General description
Lactosyl-ceramide is synthesized from complex glycosphingolipids by glucosylceramide synthase via caremide intermediate glucosylceramide.
Application
C8 Lactosyl(β) Ceramide (d18:1/8:0) is suitable for use as a substrate for endoglycoceramidase II. It is also suitable for use as a synthetic lipid standard for two-dimensional liquid chromatography−quadrupole time-of-flight mass spectrometry for lipid profiling and lipidomic analysis.
Biochem/physiol Actions
Lactosyl-β1-1′-N-octanoyl-D-erythro-sphingosine like other glycosphingolipids, stimulates caveolar endocytosis. C8-LacCer mediates clustering of β1-integrins and actin cytoskeleton reorganization in skin fibroblasts. High levels of lactosyl ceramide leads to decreased respiration leading to mitochondrial dysfunction.
Packaging
5 mL Amber Glass Screw Cap Vial (860541P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3