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经验公式（希尔记法）:
C42H79 NO8
化学文摘社编号:
分子量:
726.08
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C18:1 Galactosyl(β) Ceramide (d18:1/18:1(9Z)), Avanti Research™ - A Croda Brand 860596P, powder
InChI key
MVGFIPNJBNBHNC-VTRIZHIOSA-N
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCC/C=C\CCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](O)[C@@H](O)[C@H]1CO
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860596P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860596P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Galactosyl ceramide is essential for normal myelin function and stability. It blocks epithelial cell-human immunodeficiency virus 1 (HIV-1) virion binding.
General description
Galactosyl ceramide is a complex glycosphingolipid. It is a major component of the myelin sheath and contains a single galactose residue linked to ceramide.Galactosyl ceramide is present mainly on the surface of colonic epithelial cells, vaginal epithelium and primary mammary epithelial cells.
Packaging
5 mL Amber Glass Screw Cap Vial (860596P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Gangliosides in Health and Disease
Gangliosides in Health and Disease, 77(1), 306-318 (2018)
Pediatr Neurol
Pediatric Neurology, 77(1), 306-318 (2013)
K M Koshy et al.
Biophysical journal, 77(1), 306-318 (1999-07-02)
Divalent cations mediate a carbohydrate-carbohydrate association between the two major glycolipids, galactosylceramide (GalCer) and its sulfated form, cerebroside sulfate (CBS), of the myelin sheath. We have suggested that interaction between these glycolipids on apposed extracellular surfaces of myelin may be
S Moses Dennison et al.
Journal of virology, 88(16), 9406-9417 (2014-06-13)
Mucosal epithelial cell surface galactosylceramide (Galcer) has been postulated to be a receptor for HIV-1 envelope (Env) interactions with mucosal epithelial cells. Disruption of the HIV-1 Env interaction with such alternate receptors could be one strategy to prevent HIV-1 entry
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