产品名称
Lyso SM (d18:1), Avanti Research™ - A Croda Brand
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(N)COP([O-])(OCC[N+](C)(C)C)=O
InChI
1S/C23H49N2O5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(26)22(24)21-30-31(27,28)29-20-19-25(2,3)4/h17-18,22-23,26H,5-16,19-21,24H2,1-4H3/b18-17+/t22-,23+/m0/s1
InChI key
JLVSPVFPBBFMBE-HXSWCURESA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860600P-10mg)
pkg of 1 × 25 mg (860600P-25mg)
pkg of 1 × 5 mg (860600P-5mg)
pkg of 1 × 50 mg (860600P-50mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
Lyso SM（d18:1）已用于：
- 通过平面脂质双层中的单通道记录来研究其在存在和不存在钙调蛋白的情况下对骨骼肌ryanodine受体（RyR1）的效应
- 作为Ca2+传感器钙调蛋白（CaM）的抑制剂
- 作为圆二色性（CD）光谱的标准品，以确定脂肽各种相互作用的脂质选择性
Biochem/physiol Actions
Lyso SM（d18:1）或鞘氨醇磷酸胆碱（SPC）是一种脂质介体，具有第二信使功能。它调节ryanodine受体（RyRs），并从肌浆网/内质网释放Ca2+。Lyso SM（d18:1）充当普遍存在的Ca2+传感器钙调蛋白（CaM）的内源性抑制剂。
General description
Lyso SM（d18:1），也称为鞘氨醇磷酸胆碱（SPC），是一种生物活性脂质分子。这种溶血磷脂存在于正常的血浆、腹水和各种组织中。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860600P-10mg）
5 mL棕色玻璃螺旋盖小瓶（860600P-25mg）
5 mL棕色玻璃螺旋盖小瓶（860600P-50mg）
5 mL棕色玻璃螺旋盖小瓶（860600P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Dagmar Meyer zu Heringdorf et al.
Biochimica et biophysica acta, 1582(1-3), 178-189 (2002-06-19)
Compared to the lysophospholipid mediators, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), little information is available regarding the molecular mechanisms of action, metabolism and physiological significance of the related sphingosylphosphorylcholine (SPC). S1P and LPA have recently been established as agonists at
The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations
Juhasz T, et al.
Scientific Reports, 8(1) (2018)
The lipid mediator lysophosphatidic acid induces folding of disordered peptides with basic amphipathic character into rare conformations
Juhasz T, et al.
Scientific reports, 8(1) (2018)
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
The Journal of biological chemistry, 280(52), 43280-43280 (2006-02-25)
Dissociation of Calmodulin-Target Peptide Complexes by the Lipid Mediator Sphingosylphosphorylcholine IMPLICATIONS IN CALCIUM SIGNALING
Kovacs E, et al.
The Journal of Biological Chemistry, 285(3), 1799-1808 (2010)
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