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关于此项目
经验公式（希尔记法）:
C20H41NO3
化学文摘社编号:
分子量:
343.54
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
C2 Dihydroceramide (d18:0/2:0), Avanti Research™ - A Croda Brand 860625P, powder
SMILES string
OC[C@]([H])(NC(C)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C20H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20(24)19(17-22)21-18(2)23/h19-20,22,24H,3-17H2,1-2H3,(H,21,23)/t19-,20+/m0/s1
InChI key
CRJGESKKUOMBCT-VQTJNVASSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860625P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860625P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
Dihydroceramide belongs to the ceramide family. It contains sphinganine, which is devoid of the 4,5-trans-double bond in the sphingoid base backbone.
Application
C2 Dihydroceramide (d18:0/2:0) has been used as a lipid standard in the analysis of sphingolipids by tandem mass spectrometry. It is also suitable for inducing stress in embryos to study stress-induced apoptosis in larval embryos of Japanese flounder.
Biochem/physiol Actions
Dihydroceramide is synthesized by the N-acylation of dihydrosphingosine. It functions as an inactive precursor for ceramide in de novo sphingolipid synthesis. (Dihydro)-ceramide desaturase catalyzes the conversion of dihydroceramide to ceramide by the addition of C4−5 trans-double bond in the sphingoid backbone. Dihydroceramide has an ability to induce autophagy.
Packaging
5 mL Amber Glass Screw Cap Vial (860625P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Stress-induced apoptosis in larval embryos of Japanese flounder
Yabu T, et al.
Fisheries Science (Tokyo, Japan), 69(6), 1218-1223 (2003)
Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways
Gillard BK, et al.
Glycobiology, 8(9), 885-890 (1998)
Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model
Muralimanoharan S, et al.
Autophagy, 12(5), 752-769 (2016)
Ceramide function in the brain: when a slight tilt is enough
Mencarelli C and Martinez-Martinez, P
Cellular and Molecular Life Sciences, 70(2), 181-203 (2013)
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