产品名称
D-苏式-鞘胺醇-1-磷酸(d17:1), Avanti Research™ - A Croda Brand
InChI
1S/C17H36NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(19)16(18)15-23-24(20,21)22/h13-14,16-17,19H,2-12,15,18H2,1H3,(H2,20,21,22)/b14-13+/t16-,17+/m0/s1
InChI key
VITGNIYTXHNNNE-LHMZYYNSSA-N
SMILES string
CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@]([NH3+])([H])COP([O-])(O)=O
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860641P-1mg)
pkg of 1 × 5 mg (860641P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Application
鞘氨醇-1-磷酸（d17:1）已被用作内标，通过质谱对生物学材料和组织样品中的鞘氨醇-1-磷酸（S1P）进行定量。
Biochem/physiol Actions
鞘氨醇-1-磷酸（S1P）可有助于细胞的生长和功能。它还有助于多种生理和细胞过程，如动脉粥样硬化、炎症、免疫、肿瘤发生和细胞增殖。S1P在动物细胞中可起到信号脂质的作用。
General description
鞘氨醇-1-磷酸（S1P）（d17:1）是神经酰胺的一种衍生物。它是鞘氨醇C17类似物的磷酸化形式。S1P是一种两性鞘脂。它存在于昆虫、酵母和植物中。
Packaging
5 mL 棕色玻璃螺旋盖小瓶 (860641P-1mg)
5 mL 棕色玻璃螺旋盖小瓶 (860641P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Cecilia Frej et al.
Analytical and bioanalytical chemistry, 407(28), 8533-8542 (2015-09-18)
Sphingosine 1-phosphate (S1P) is a signalling sphingolipid affecting multiple cellular functions of vascular and immune systems. It circulates at submicromolar levels bound to HDL-associated apolipoprotein M (apoM) or to albumin. S1P in blood is mainly produced by platelets and erythrocytes
Constantin Bode et al.
Methods in molecular biology (Clifton, N.J.), 874, 33-44 (2012-04-25)
Liquid chromatography coupled to tandem mass spectrometry has evolved as the method of choice for the detection of sphingolipid metabolites due to its high sensitivity and superior specificity compared to other methodological approaches. Here, we describe a simple and robust
Mina Mirzaian et al.
Clinica chimica acta; international journal of clinical chemistry, 459, 36-44 (2016-05-26)
We developed a mass spectrometric procedure to quantify sphingosine-1-phosphate (S1P) in biological materials. The use of newly synthesized (13)C5 C18-S1P and commercial C17-S1P as internal standards rendered very similar results with respect to linearity, limit of detection and limit of
Eri Sakai et al.
The journal of applied laboratory medicine, 5(4), 656-670 (2020-05-15)
Sphingolipids have been demonstrated to be involved in many human diseases. However, measurement of sphingolipids, especially of sphingosine 1-phosphate (S1P) and dihydro-sphingosine 1-phosphate (dhS1P), in blood samples requires strict sampling, since blood cells easily secrete these substances during sampling and
Pernille M Christensen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(6), 2351-2359 (2016-03-10)
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn
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