产品名称
C8 Ceramide (d17:1/8:0), Avanti Research™ - A Croda Brand 860645P, powder
InChI
1S/C25H49NO3/c1-3-5-7-9-10-11-12-13-14-15-17-18-20-24(28)23(22-27)26-25(29)21-19-16-8-6-4-2/h18,20,23-24,27-28H,3-17,19,21-22H2,1-2H3,(H,26,29)/b20-18+/t23-,24+/m0/s1
InChI key
YUKGJYMYMCFXEF-VYQUXUJXSA-N
SMILES string
OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCC
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 10 mg (860645P-10mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860645P
shipped in
dry ice
storage temp.
−20°C
Application
C8 Ceramide (d17:1/8:0) has been used to induce myriocin-treated malignant melanoma cells to increase endogenous ceramide levels.
General description
C8-ceramide or N-octanoyl-D-erythro-sphingosine (C17 base) is a synthetic cell-permeable sphingolipid. It is a combination of C17 analog of sphingosine and octanoic acid. Ceramides are the major lipid component in the outermost layer of the skin, the stratum corneum. C8 Ceramide plays a vital role in inducing apoptotic cell death.
Packaging
5 mL Amber Glass Screw Cap Vial (860645P-10mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
J P Witty et al.
Endocrinology, 137(12), 5269-5277 (1996-12-01)
Recent studies have demonstrated that ovarian follicle atresia occurs extensively before follicle selection into the avian preovulatory hierarchy, and that this process is mediated via granulosa cell apoptosis. Subsequent to follicle selection, granulosa cells are inherently resistant to apoptosis, and
Y-S Lee et al.
Cell proliferation, 44(4), 320-329 (2011-06-08)
Melanoma is the most aggressive form of skin cancer, and it resists chemotherapy. Candidate drugs for effective anti-cancer treatment have been sought from natural resources. Here, we have investigated anti-proliferative activity of myriocin, serine palmitoyltransferase inhibitor, in the de novo
Luisa Coderch et al.
American journal of clinical dermatology, 4(2), 107-129 (2003-01-30)
Ceramides are the major lipid constituent of lamellar sheets present in the intercellular spaces of the stratum corneum. These lamellar sheets are thought to provide the barrier property of the epidermis. It is generally accepted that the intercellular lipid domain
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