产品名称
C8 1-磷酸神经酰胺 (d17:1/8:0), Avanti Research™ - A Croda Brand 860652P, powder
InChI key
QZINIJMZYDYICQ-ITEYRTANSA-N
SMILES string
CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@@]([H])(NC(CCCCCCC)=O)COP([O-])(O)=O.[NH4+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860652P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860652P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
1-磷酸神经酰胺（C1P）充当促有丝分裂剂。它具有抗凋亡和生存特性。C1P刺激炎症反应并促进吞噬作用。它还具有负调节脂多糖诱导的肿瘤坏死因子-α（TNFα）产生的能力。C1P被认为是激动剂刺激的鞘磷脂代谢的第二个脂质信使。
General description
C8 1-磷酸神经酰胺 (d17:1/8:0)是一种新型的生物活性鞘脂。由神经酰胺激酶（CERK）催化C8-神经酰胺或N-辛酰基-D-赤型-鞘氨醇（C17碱）磷酸化形成。C1P是磷脂酸盐的鞘脂类似物。
Packaging
5 mL棕色玻璃螺旋盖小瓶（860652P-1mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Tack-Joong Kim et al.
Experimental cell research, 317(14), 2041-2051 (2011-06-01)
Ceramide 1-phosphate (C1P) is a novel bioactive sphingolipid formed by ceramide kinase (CERK)-catalyzed phosphorylation of ceramide. It has been implicated in the regulation of such vital pathophysiological functions as phagocytosis and inflammation, but there have been no reports ascribing a
Szczepan Józefowski et al.
Journal of immunology (Baltimore, Md. : 1950), 185(11), 6960-6973 (2010-11-03)
LPS is a constituent of cell walls of Gram-negative bacteria that, acting through the CD14/TLR4 receptor complex, causes strong proinflammatory activation of macrophages. In murine peritoneal macrophages and J774 cells, LPS at 1-2 ng/ml induced maximal TNF-α and MIP-2 release
Lide Arana et al.
Lipids in health and disease, 9, 15-15 (2010-02-09)
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes. Two major actions of ceramides are the promotion of cell cycle arrest and the induction
Antonio Gómez-Muñoz et al.
Journal of lipid research, 45(1), 99-105 (2003-10-03)
It was reported previously that ceramide-1-phosphate (Cer-1-P) is mitogenic for fibroblasts (Gómez-Muñoz, A., P. A. Duffy, A. Martin, L. O'Brien, H-S. Byun, R. Bittman, and D. N. Brindley. 1995. Mol. Pharmacol. 47: 883-889; Gómez-Muñoz, A., L. M. Frago, L. Alvarez
V T Hinkovska-Galcheva et al.
The Journal of biological chemistry, 273(50), 33203-33209 (1998-12-05)
Ceramide, a product of agonist-stimulated sphingomyelinase activation, is known to be generated during the phagocytosis of antibody-coated erythrocytes by polymorphonuclear leukocytes. Agonist-stimulated formation of ceramide-1-phosphate is now shown to occur in 32PO4-labeled neutrophils. Ceramide-1-phosphate is formed by a calcium-dependent ceramide
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持