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Merck
CN

860657P

Avanti

鞘氨醇-d7

Avanti Research - A Croda Brand

别名:

D-赤型-鞘氨醇-d7

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关于此项目

经验公式(希尔记法):
C18H30D7NO2
化学文摘社编号:
分子量:
306.54
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
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产品名称

鞘氨醇-d7, Avanti Research - A Croda Brand

InChI key

WWUZIQQURGPMPG-AVMMVCTPSA-N

SMILES string

OC[C@@](N)([H])[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860657P-1mg)
pkg of 1 × 5 mg (860657P-5mg)

manufacturer/tradename

Avanti Research - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

Application

鞘氨醇-d7已被用作液相色谱-串联质谱法的内标,用于定量分析生物样品中的鞘脂。

Biochem/physiol Actions

鞘氨醇负调节细胞增殖并诱导凋亡。它具有调节磷脂酶,蛋白激酶,离子通道,大麻素受体1型(CB-1)受体和类固醇生成因子1(SF-1)受体活性的能力。鞘氨醇是用于合成乙酰胆碱的前体。

General description

鞘氨醇-d7是鞘氨醇的氘代衍生物。鞘氨醇是一种重要的生物活性鞘脂代谢产物。它是一种源自鞘磷脂的18碳氨基醇。鞘氨醇含有不饱和烃链。

Packaging

5 mL棕色玻璃螺旋盖小瓶(860657P-1mg)
5 mL棕色玻璃螺旋盖小瓶(860657P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

法规信息

美国出口管控产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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the
Lipid Mediators and Their Metabolism in the Brain (2011)
Iulia Zoicas et al.
Cells, 9(5) (2020-05-24)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpression of Asm (Asm-tgfb)
Stephanie Schwalm et al.
The American journal of pathology, 187(11), 2413-2429 (2017-08-16)
Kidney fibrosis is a hallmark of chronic kidney disease and leads to extracellular matrix accumulation, organ scarring, and loss of kidney function. In this study, we investigated the role of sphingosine kinase-2 (SPHK2) on the progression of tubular fibrosis by
Henning Carstens et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(6), 1015-1028 (2019-12-20)
Pulmonary infections with Pseudomonas aeruginosa (P. aeruginosa) or Staphylococcus aureus (S. aureus) are of utmost clinical relevance in patients with cystic fibrosis, chronic obstructive pulmonary disease, after trauma and burn, upon ventilation or in immuno-compromised patients. Many P. aeruginosa and
Olivier Cuvillier
Biochimica et biophysica acta, 1585(2-3), 153-162 (2003-01-18)
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a

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