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经验公式（希尔记法）:
C18H32D7NO2
化学文摘社编号:
分子量:
308.55
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
sphinganine-d7, Avanti Research™ - A Croda Brand 860658P, powder
InChI
1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1/i1D3,2D2,3D2
InChI key
OTKJDMGTUTTYMP-GEZFCKIXSA-N
SMILES string
OC[C@@](N)([H])[C@@](O)([H])CCCCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860658P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860658P
shipped in
dry ice
storage temp.
−20°C
Application
Sphinganine-d7 has been used as an internal standard for quantification of sphingolipid concentrations in plasma and tissue samples by high-performance liquid chromatography tandem mass spectrometry.
Biochem/physiol Actions
Sphinganine (SPA) acts as a selective inhibitor of protein kinase C in intact human neutrophils. It may function a potential biomarker for the diagnosis of sphingolipidoses. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.
General description
Sphinganine-d7 is a deuterated derivative of sphinganine. Sphinganine, also called as dihydrosphingosine is a derivative of sphingosine. Sphinganines are produced in endoplasmic reticulum, by decarboxylating condensation of palmitoyl-CoA and serine.
Packaging
5 mL Amber Glass Screw Cap Vial (860658P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
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