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经验公式（希尔记法）:
C14H29NO2
化学文摘社编号:
分子量:
243.39
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
Sphingosine (d14:1), Avanti Research™ - A Croda Brand 860670P, powder
InChI
1S/C14H29NO2/c1-2-3-4-5-6-7-8-9-10-11-14(17)13(15)12-16/h10-11,13-14,16-17H,2-9,12,15H2,1H3/b11-10+/t13-,14+/m0/s1
InChI key
VDRZDTXJMRRVMF-NXFSIWHZSA-N
SMILES string
OC[C@@](N)([H])[C@]([H])(O)/C=C/CCCCCCCCC
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (860670P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860670P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Sphingosine acts as a negative regulator of cell proliferation. It induces apoptosis. It modulates the activities of enzymes such as, phospholipases and protein kinases. In addition, sphingosine also regulate ion channels, cannabinoid receptor type 1 (CB-1) receptors and steroidogenic factor 1 (SF-1) receptors.
General description
Sphingosine (d14:1), also referred as tetradecasphing-4-enine, is a C14 analog of sphingosine. It is a major part of sphingoid bases in Musca domestica larvae and adults.
Packaging
5 mL Amber Glass Screw Cap Vial (860670P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
the
Lipid Mediators and Their Metabolism in the Brain (2011)
The occurrence of tetradecasphing-4-enine and hexadecasphing-4-enine as the principal sphingosines of Musca domestica larvae and adults.
L L Bieber et al.
Biochimica et biophysica acta, 187(1), 157-159 (1969-07-29)
Olivier Cuvillier
Biochimica et biophysica acta, 1585(2-3), 153-162 (2003-01-18)
The sphingolipid metabolites ceramide, sphingosine, and sphingosine 1-phosphate contribute to controlling cell proliferation and apoptosis. Ceramide and its catabolite sphingosine act as negative regulators of cell proliferation and promote apoptosis. Conversely, sphingosine 1-phosphate, formed by phosphorylation of sphingosine by a
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