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关于此项目
经验公式（希尔记法）:
C34H60D7NO3
化学文摘社编号:
分子量:
544.94
MDL number:
UNSPSC Code:
12352100
NACRES:
NA.12
产品名称
C16 神经酰胺-d7 (d18:1-d7/16:0), Avanti Research™ - A Croda Brand 860676P, powder
InChI
1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1/i1D3,3D2,5D2
InChI key
YDNKGFDKKRUKPY-HJSOYJPBSA-N
SMILES string
OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@@](O)([H])/C=C/CCCCCCCCCCC(C(C([2H])([2H])[2H])([2H])[2H])([2H])[2H]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (860676P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860676P
shipped in
dry ice
storage temp.
−20°C
Application
C16神经酰胺-d7(d18:1-d7/16:0)已被用作通过液相色谱-质谱（LC-MS）联用法测定骨骼肌中C16神经酰胺含量的标准品。
Biochem/physiol Actions
C16神经酰胺在细胞凋亡信号转导中起着至关重要的作用。检查人血浆中神经酰胺（Cer）d18:1/16:0、Cer d18:1/18:0、 Cer d18:1/24:0和 Cer d18:1/24:的水平及其比率有助于冠状动脉疾病致命结果的预后。一种经过验证的新液相色谱-串联质谱分析方法采用稳定同位素形式的C16神经酰胺（d18：1/16：0）进行临床规模的测量。
General description
C16神经酰胺（d18:1/16:0）是一种含有鞘氨醇和棕榈酸的合成神经酰胺。它是由神经酰胺合成酶 6（CerS6）合成的。C16神经酰胺-d7（d18:1-d7/16:0）是神经酰胺d18:1/16:0的氘代衍生物。
Packaging
5 mL 棕色玻璃螺旋盖小瓶 (860676P-1 mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
法规信息
美国出口管控产品
此项目有
S White-Gilbertson et al.
Oncogene, 28(8), 1132-1141 (2009-01-13)
We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) induces an increase of intracellular C(16)-ceramide in sensitive SW480 but not in resistant SW620 cells. Resistance in SW620 cells was overcome by exogenous ceramide, leading
Paul T Reidy et al.
The Journal of physiology, 596(21), 5217-5236 (2018-09-09)
Insulin sensitivity (as determined by a hyperinsulinaemic-euglyceamic clamp) decreased 15% after reduced activity. Despite not fully returning to baseline physical activity levels, insulin sensitivity unexpectedly, rebounded above that recorded before 2 weeks of reduced physical activity by 14% after the recovery
Anna Zalewska et al.
Biomolecules, 9(12) (2019-12-19)
This is the first study to investigate the relationship between ceramides, the mitochondrial respiratory system, oxidative stress, inflammation, and apoptosis in the submandibular gland mitochondria of mice with insulin resistance (IR). The experiment was conducted on 20 male C57BL/6 mice
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
Hady Razak Hady et al.
Journal of clinical medicine, 8(12) (2019-12-18)
The liver plays a central role in the glucose and lipid metabolism. Studies performed on animal models have shown an important role of lipid accumulation in the induction of insulin resistance. We sought to explain whether in obese humans, the
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