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Merck
CN

860843P

Avanti

18:0(2S-OH) Sulfo GalCer

Avanti Research™ - A Croda Brand

别名:

3-O-sulfo-D-galactosyl-β1-1′-N-[2"(S)-hydroxystearoyl]-D-erythro-sphingosine (ammonium salt), (synthetic)

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关于此项目

经验公式（希尔记法）:
C42H84N2O12S
化学文摘社编号:
2260670-28-6
分子量:
841.19
UNSPSC Code:
12352211
NACRES:
NA.25

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产品名称

18:0(2S-OH) Sulfo GalCer, Avanti Research™ - A Croda Brand 860843P, powder

InChI

1S/C42H81NO12S.H3N/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-36(46)41(49)43-34(35(45)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)33-53-42-39(48)40(55-56(50,51)52)38(47)37(32-44)54-42;/h28,30,34-40,42,44-48H,3-27,29,31-33H2,1-2H3,(H,43,49)(H,50,51,52);1H3/b

InChI key

SPENGCIMZSSNON-AKPGGMFPSA-N

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC([C@@H](O)CCCCCCCCCCCCCCCC)=O)CO[C@H](O1)[C@H](O)[C@@H](OS([O-])(=O)=O)[C@H]([C@H]1CO)O.[NH4+]

assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (860843P-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860843P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

General description

18:0(2S-OH) Sulfo GalCer, also known as 3-O-sulfo-D-galactosyl-β1-1′-N-[2"(S)-hydroxystearyl]-D-erythro-sphingosine, is a sulfatide derived from 18:0(2S-OH) GalCer via esterification of a sulfate group to 3-hydroxyl of the galactose moiety. It is a vital constituent of the membranous myelin sheath.

Biochem/physiol Actions

Sulfatides or sulfo-galactosylceramide (S-GalCer) plays a vital role in protein trafficking, signal transduction and neuronal cell differentiation. Elevated levels of S-GalCer in lysosomes due to arylsulfatase A (ASA) deficiency leads to the development of metachromatic leukodystrophy in humans.

Packaging

5 mL Amber Glass Screw Cap Vial (860843P-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

存储类别

11 - Combustible Solids

flash_point_f

No data available

flash_point_c

No data available

法规信息

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分析证书(COA)

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Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 116(2), 223-249 (2008)
Analysis of complex lipidomes
Medical Applications of Mass Spectrometry, 116(2), 223-249 (2008)
R Lüllmann-Rauch et al.
Histochemistry and cell biology, 116(2), 161-169 (2001-10-31)
The inherited deficiency of arylsulfatase A (ASA) causes lysosomal accumulation of sulfoglycolipids (mainly sulfo-galactosylceramide, S-GalCer ) and leads to metachromatic leukodystrophy in humans. Among visceral organs, kidneys are particularly affected. In the present study, the regional distribution and temporal development

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