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关于此项目
经验公式（希尔记法）:
C50H99NO9
化学文摘社编号:
分子量:
858.32
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
SMILES string
O[C@]([H])(CCCCCCCCCCCCCC)[C@](O)([H])[C@@]([H])(NC(CCCCCCCCCCCCCCCCCCCCCCCCC)=O)CO[C@@H](O1)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
InChI
1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42?,43-,44-,46+,47+,48+,49-,50+/m1/s1
InChI key
VQFKFAKEUMHBLV-VDYNBUGPSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (867000P-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
General description
αα-半乳糖基神经酰胺(KRN7000)是恒定自然杀伤T细胞(iNKT)的高亲和性糖脂配体。具有1个α-半乳糖基神经酰胺核心和1个agelasphin-9b神经酰胺核心变体。它是来自海绵的半乳糖神经酰胺(α‐GalCer)的合成同系物。由长链脂肪酰(C26)和鞘氨醇碱基(C18)组成。
Application
αα-半乳糖基神经酰胺(KRN7000)已用于自然杀伤细胞的体外刺激。适合用作骨髓来源细胞(BMDC)和原代肝细胞的脂质抗原，以便进行抗原提呈试验。也适合作为配体激活恒定自然杀伤T细胞(iNKT)。
Biochem/physiol Actions
αα-半乳糖基神经酰胺(KRN7000)给药导致辅助性T细胞(TH0)或TH2细胞因子应答。在各种体外模型中表现强效的抗肿瘤活性，比如B6黑色素瘤、结肠腺癌Colon26和肝转移瘤。
Packaging
5 mL棕色玻璃螺旋盖小瓶(867000P-1mg)
Other Notes
未在日本市场销售
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
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