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经验公式（希尔记法）:
C34H36NO3D31
化学文摘社编号:
分子量:
569.09
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
16:0-d31 Ceramide, Avanti Research™ - A Croda Brand 868516P, powder
InChI key
YDNKGFDKKRUKPY-MFTNTAGNSA-N
SMILES string
[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O)CO
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (868516P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 868516P
shipped in
dry ice
storage temp.
−20°C
General description
Ceramide is a N-acylsphingosine derived mainly from sphingomyelin (SM) or sphingosine (Sph) by acidic sphingomyelinase (ASMase) during sphingolipid (SPL) biosynthesis and degradation pathways. It is a mostly studied SPL mediator.
Application
16:0-d31 Ceramide is suitable for use as an internal standard for quantification of N-palmitoyl-D-erythro-sphingosine (C16-ceramide) levels by liquid chromatography/mass spectrometry (LC-MS).
Biochem/physiol Actions
Ceramide plays an important role in various processes including, cellular differentiation, apoptosis and cell signaling pathways.
Packaging
5 mL Amber Glass Screw Cap Vial (868516P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice
Matsubara T, et al.
Hepatology, 53(4), 1282-1293 (2011)
Enhancing cardiac triacylglycerol metabolism improves recovery from ischemic stress
Kolwicz SC, et al.
Molecular and Cellular Endocrinology, 64(8), 2817-2827 (2015)
Ambika T Singh et al.
Molecular and cellular endocrinology, 362(1-2), 48-59 (2012-06-02)
Sphingolipid mediators such as ceramide are pleiotropic regulators of cellular growth, differentiation and apoptosis. We investigated the role of ceramide biosynthesis, metabolism and actions in term human cytotrophoblasts syncytialized over 7 days in culture. Intracellular C16 ceramide levels increased modestly
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