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Merck
CN

870601C

Avanti

Azelaoyl-PAF

Avanti Research™ - A Croda Brand

别名:

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine

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关于此项目

经验公式（希尔记法）:
C33H66NO9P
化学文摘社编号:
354583-69-0
分子量:
651.85
MDL编号:
MFCD03412018
UNSPSC代码:
12352211
NACRES:
NA.25

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产品名称

Azelaoyl-PAF, Avanti Research™ - A Croda Brand 870601C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (870601C-1mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 870601C

浓度

1 mg/mL (870601C-1mg)

运输

dry ice

储存温度

−20°C

SMILES字符串

[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCC(O)=O)=O)COCCCCCCCCCCCCCCCC)=O

InChI

1S/C33H66NO9P/c1-5-6-7-8-9-10-11-12-13-14-15-16-20-23-27-40-29-31(30-42-44(38,39)41-28-26-34(2,3)4)43-33(37)25-22-19-17-18-21-24-32(35)36/h31H,5-30H2,1-4H3,(H-,35,36,38,39)/t31-/m1/s1

InChI key

ZDFOCDTXDPKJKA-WJOKGBTCSA-N

相关类别

一般描述

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (Azelaoyl-PAF) Azelaoyl-PAF is an alkyl phosphatidylcholine and is a component of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles. Azelaoyl-PAF is a low molecular weight phospholipid.

应用

Azelaoyl-PAF may be used in binding assay of anti-inflammatory peptides, 2F and 4F.

生化/生理作用

1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine (Azelaoyl-PAF) acts as an agonist for peroxisome proliferator-activated receptors γ(PPAR-γ). It may be used as a therapeutic for Friedreich′s ataxia (FRDA). At low concentrations azelaoyl-PAF may induce apoptosis.

包装

5 mL Clear Glass Sealed Ampule (870601C-1mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

WGK

WGK 3

法规信息

易制毒化学品（2类）
危险化学品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Anti-inflammatory peptides grab on to the whiskers of atherogenic oxidized lipids
Epand RF, et al.
Biochimica et Biophysica Acta - Biomembranes, 1788(9), 1967-1975 (2009)
PPAR-gamma agonist azelaoyl PAF increases frataxin protein and mRNA expression. New implications for the friedreich?s ataxia therapy
Marmolino D, et al.
Cerebellum, 8(2), 98-103 (2009)
P Tontonoz et al.
Cell, 93(2), 241-252 (1998-05-06)
The formation of foam cells from macrophages in the arterial wall is characterized by dramatic changes in lipid metabolism, including increased expression of scavenger receptors and the uptake of oxidized low-density lipoprotein (oxLDL). We demonstrate here that the nuclear receptor
S S Davies et al.
The Journal of biological chemistry, 276(19), 16015-16023 (2001-03-30)
Synthetic high affinity peroxisome proliferator-activated receptor (PPAR) agonists are known, but biologic ligands are of low affinity. Oxidized low density lipoprotein (oxLDL) is inflammatory and signals through PPARs. We showed, by phospholipase A(1) digestion, that PPARgamma agonists in oxLDL arise
Douglas S Watson et al.
Vaccine, 27(34), 4672-4683 (2009-06-13)
The membrane proximal region (MPR) of HIV-1 gp41 is a desirable target for development of a vaccine that elicits neutralizing antibodies since the patient-derived monoclonal antibodies, 2F5 and 4E10, bind to the MPR and neutralize primary HIV isolates. The 2F5

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