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关于此项目
经验公式（希尔记法）:
C29H56NO10P
化学文摘社编号:
分子量:
609.73
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
PGPC, Avanti Research™ - A Croda Brand 870602P, powder
InChI
1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1
InChI key
CDZVJFRXJAUXPP-AREMUKBSSA-N
SMILES string
[O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCC(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O)=O
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (870602P-1mg), pkg of 1 × 5 mg (870602P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 870602P
shipped in
dry ice
storage temp.
−20°C
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General description
1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC） 是氧化修饰的低密度脂蛋白（oxLDL） 的一种成分。它是由一种主要的低密度脂蛋白（LDL） 磷脂 1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC）的非酶氧化合成的。
Application
1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC） 已被用于使用单分子显微镜研究其对质膜纳米平台的影响。
Biochem/physiol Actions
1-棕榈酰-2-戊二酰-sn-甘油-3-磷酸胆碱（PGPC）在培养的血管平滑肌细胞和巨噬细胞中充当炎症、增殖或凋亡的诱导剂。它在动脉粥样硬化病变中积累。
Packaging
5 mL透明玻璃密封安瓿（870602P-1mg）
5 mL透明玻璃密封安瓿（870602P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
The role of high-density lipoproteins in oxidation and inflammation
Van Lenten B, et al.
Trends in Cardiovascular Medicine, 11(3-4), 155-161 (2001)
The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells
Fruhwirth GO, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1761(9), 1060-1069 (2006)
Oxidized phospholipids inhibit the formation of cholesterol-dependent plasma membrane nanoplatforms
Brameshuber M, et al.
Biophysical Journal, 110(1), 205-213 (2016)
Alexandra Moumtzi et al.
Journal of lipid research, 48(3), 565-582 (2006-12-01)
Lipid oxidation is now thought to be an initiating and sustaining event in atherogenesis. Oxidatively fragmented phospholipids, namely 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC) and 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC), present in minimally modified LDL and atherosclerotic lesions, have been reported to elicit a wide range of
Marco Di Gioia et al.
Nature immunology, 21(1), 42-53 (2019-11-27)
Pathogen-associated molecular patterns (PAMPs) have the capacity to couple inflammatory gene expression to changes in macrophage metabolism, both of which influence subsequent inflammatory activities. Similar to their microbial counterparts, several self-encoded damage-associated molecular patterns (DAMPs) induce inflammatory gene expression. However
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