SMILES string
C[N+](C)(C)C[C@H](OC(CCCCCCCCCCCCCCC)=O)CC([O-])=O
InChI
1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3
InChI key
XOMRRQXKHMYMOC-UHFFFAOYSA-N
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (870851P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
lipid type
bioactive lipids
shipped in
dry ice
storage temp.
−20°C
General description
C16肉毒碱，也称为棕榈酰L-肉碱，是一种内源性酰基肉碱。在结构上含有左旋肉碱（L-carnitine）头基和16碳饱和脂肪酸尾。棕榈酰L-肉碱是通过棕榈酰-CoA酯与肉碱的可逆反应衍生的。棕榈酰L-肉碱通过肉毒碱棕榈酰转移酶II转运穿过内膜进行β-氧化。
Application
C16肉毒碱或棕榈酰L-肉碱已用于研究其对甘氨酸转运蛋白活性的影响。
Biochem/physiol Actions
C16肉碱具有抑制甘氨酸转运蛋白2（GlyT2）的潜力。它是β-氧化的关键能量供体。棕榈酰肉碱激活骨骼肌肌浆网的Ca2+释放通道。由于棕榈酰转移酶II缺乏引起的棕榈酰L-肉碱水平升高会导致能量代谢的常染色体隐性遗传疾病，主要影响骨骼肌。
Packaging
5 mL棕色玻璃螺旋盖小瓶（870851P-5mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
R el-Hayek et al.
Biophysical journal, 65(2), 779-789 (1993-08-01)
Studies of [3H]ryanodine binding, 45Ca2+ efflux, and single channel recordings in planar bilayers indicated that the fatty acid metabolite palmitoyl carnitine produced a direct stimulation of the Ca2+ release channel (ryanodine receptor) of rabbit and pig skeletal muscle junctional sarcoplasmic
An explorative study of the effect of apple and apple products on the human plasma metabolome investigated by LC--MS profiling
Rago D, et al.
Metabolomics, 11(1), 27-39 (2015)
Oleoyl-l-carnitine inhibits glycine transport by G ly T 2
Carland JE, et al.
British Journal of Pharmacology, 168(4), 891-902 (2013)
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