产品名称
Chol-PEG600, Avanti Research™ - A Croda Brand 880001M, methylene chloride solution
SMILES string
O(C1CCC2(C3C(C4C(C(CC4)C(CCCC(C)C)C)(CC3)C)CC=C2C1)C)CCO
InChI
1S/C29H50O2/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(31-18-17-30)13-15-28(22,4)27(24)14-16-29(25,26)5/h9,20-21,23-27,30H,6-8,10-19H2,1-5H3
InChI key
NPYXBHZQVNRAOF-UHFFFAOYSA-N
assay
>99% (TLC)
form
methylene chloride solution
packaging
pkg of 1 × 2.5 mL (880001M-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880001M
concentration
10 mg/mL (880001M-25mg)
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
PEG-cholesterol is mainly used in preparation of lipoplexes for DNA transfection studies, and liposomes for encapsulated drug delivery.
General description
Chol-PEG600, also known as cholesterol-(polyethylene glycol-600), is a derivative of cholesterol and is a nonionic amphipathic lipid. Structurally, it comprises lipophilic cholesterol and covalently bound hydrophilic PEG.
Packaging
5 mL Clear Glass Sealed Ampule (880001M-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
wgk
WGK 2
法规信息
新产品
此项目有
Poly (ethylene glycol)-cholesterol inhibits L-type Ca2+ channel currents and augments voltage-dependent inactivation in A7r5 cells
Ochi, R, et al.
Testing, 9(9) (2014)
Poly (ethylene glycol)-cholesterol inhibits L-type Ca2+ channel currents and augments voltage-dependent inactivation in A7r5 cells
Ochi, R, et al.
PLoS ONE, 9(9) (2014)
Rikuo Ochi et al.
PloS one, 9(9), e107049-e107049 (2014-09-10)
Cholesterol distributes at a high density in the membrane lipid raft and modulates ion channel currents. Poly(ethylene glycol) cholesteryl ether (PEG-cholesterol) is a nonionic amphipathic lipid consisting of lipophilic cholesterol and covalently bound hydrophilic PEG. PEG-cholesterol is used to formulate
CHOBIMALT: a cholesterol-based detergent
Howell S, et al.
Biochemistry, 49(44), 9572-9583 (2010)
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