产品名称
DSPE-PEG(5000) Folate, Avanti Research™ - A Croda Brand 880123P, powder
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 500 μg (880123P-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880123P
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]
General description
DSPE-PEG(5000) Folate is a conjugate of folic acid and amino-PEG-DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol).
Biochem/physiol Actions
Folate receptors are cellular surface markers for numerous solid tumors. DSPE-PEG-folate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) incorporated into liposomes serves as a targeting ligand. Folate targeted drug delivery is useful in diagnosing and treating cancer and inflammatory diseases. Many molecules such as toxins (proteinaceous), immune stimulators and anti-cancer drugs can be delivered to folate receptor.
Packaging
5 mL Amber Glass Screw Cap Vial (880123P-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery, 48-48 (2014)
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
Hilgenbrink AR and Low PS
Journal of Pharmaceutical Sciences, 94(10), 2135-2146 (2005)
Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging
Nakamura T, et al.
Biological & Pharmaceutical Bulletin, 37(4), 521-527 (2014)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 880123P-500UG | 04061835192311 |