880123P
Avanti
DSPE-PEG(5000) Folate
Avanti Research™ - A Croda Brand
别名:
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt)
产品名称
DSPE-PEG(5000) Folate, Avanti Research™ - A Croda Brand 880123P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1 × 500 μg (880123P-500ug)
制造商/商品名称
Avanti Research™ - A Croda Brand 880123P
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]
一般描述
DSPE-PEG(5000) Folate is a conjugate of folic acid and amino-PEG-DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-(polyethylene glycol).
生化/生理作用
Folate receptors are cellular surface markers for numerous solid tumors. DSPE-PEG-folate (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) incorporated into liposomes serves as a targeting ligand. Folate targeted drug delivery is useful in diagnosing and treating cancer and inflammatory diseases. Many molecules such as toxins (proteinaceous), immune stimulators and anti-cancer drugs can be delivered to folate receptor.
包装
5 mL Amber Glass Screw Cap Vial (880123P-500ug)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery, 48-48 (2014)
Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging
Nakamura T, et al.
Biological & Pharmaceutical Bulletin, 37(4), 521-527 (2014)
Zhaoyan Yang et al.
ACS applied materials & interfaces, 11(51), 47671-47679 (2019-10-22)
Lead halide perovskite nanocrystals (NCs) are promising optical materials in many fields. However, their poor moisture stability, significant toxicity, and difficulty to be further functionalized greatly hinder their applications in bioimaging. Here, a universal strategy is demonstrated by simply encapsulating
Folate receptor-mediated drug targeting: from therapeutics to diagnostics
Hilgenbrink AR and Low PS
Journal of Pharmaceutical Sciences, 94(10), 2135-2146 (2005)
Shih-Jiuan Chiu et al.
Journal of controlled release : official journal of the Controlled Release Society, 112(2), 199-207 (2006-03-28)
A novel transferrin receptor (TfR)-targeted liposomal formulation was synthesized and evaluated for the delivery of a phosphorothioate antisense oligodeoxyribonucleotide (ODN) (G3139, oblimerson sodium, or Genasense) to Bcl-2 in K562 leukemia cells. Liposomes composed of DC-Chol/egg PC/PEG-DSPE (25:73.5:1.5, mol/mol/mol) were loaded
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