产品名称
DSPE-PEG(5000) Folate, Avanti Research™ - A Croda Brand 880123X
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (880123X-500ug)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880123X
concentration
0.5 mg/mL (880123X-500ug)
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]
General description
DSPE-PEG(5000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) is incorporated into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for various cancers and myeloid leukemias. Folate targeted drug delivery is potentially used for the treatment and imaging of several cancers and inflammatory diseases. Folate conjugates are small molecules having high binding affinity for folate receptors (FR) on cell surface. Therefore, they have an ability to deliver a variety of molecular complexes to pathologic cells without affecting normal tissues.
Application
DSPE-PEG(5000) Folate may be used:
- in preparation of folate functionalized nanoparticles (NPs)
- in synthesis of BTPEPBI-containing nanoparticles
- in preparation of paclitaxel loaded folate modified lipid-shell and polymer-core nanoparticles (FLPNPs)
Packaging
5 mL Clear Glass Sealed Ampule (880123X-500ug)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
signalword
Danger
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Linhua Zhang et al.
International journal of nanomedicine, 10, 2101-2114 (2015-04-07)
The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a
Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging
Zhao Q, et al.
Journal of Materials Chemistry, 22(30), 15128-15135 (2012)
Folate-modified lipid--polymer hybrid nanoparticles for targeted paclitaxel delivery
Zhang L, et al.
International journal of nanomedicine, 10, 2101-2101 (2015)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 880123X-500UG | 04061837668227 |