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Merck
CN

880123X

Avanti

DSPE-PEG(5000) Folate

Avanti Research™ - A Croda Brand

别名:

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000] (ammonium salt):methanol (9:1)

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化学文摘社编号:
1236288-25-7
UNSPSC代码:
12352211
NACRES:
NA.25

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产品名称

DSPE-PEG(5000) Folate, Avanti Research™ - A Croda Brand 880123X

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 1 mL (880123X-500ug)

制造商/商品名称

Avanti Research™ - A Croda Brand 880123X

浓度

0.5 mg/mL (880123X-500ug)

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113]NC(CC[C@H](NC(C1=CC=C(NCC(C=N2)=NC3=C2N=C(N)NC3=O)C=C1)=O)C([O-])=O)=O)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+]

相关类别

一般描述

DSPE-PEG(5000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-5000]) is incorporated into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for various cancers and myeloid leukemias. Folate targeted drug delivery is potentially used for the treatment and imaging of several cancers and inflammatory diseases. Folate conjugates are small molecules having high binding affinity for folate receptors (FR) on cell surface. Therefore, they have an ability to deliver a variety of molecular complexes to pathologic cells without affecting normal tissues.

应用

DSPE-PEG(5000) Folate may be used:
  • in preparation of folate functionalized nanoparticles (NPs)
  • in synthesis of BTPEPBI-containing nanoparticles
  • in preparation of paclitaxel loaded folate modified lipid-shell and polymer-core nanoparticles (FLPNPs)

包装

5 mL Clear Glass Sealed Ampule (880123X-500ug)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3

靶器官

Central nervous system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Folate-modified lipid--polymer hybrid nanoparticles for targeted paclitaxel delivery
Zhang L, et al.
International journal of nanomedicine, 10, 2101-2101 (2015)
Lipid-PEG-Folate Encapsulated Nanoparticles with Aggregation Induced Emission Characteristics: Cellular Uptake Mechanism and Two-Photon Fluorescence Imaging
Geng J, et al.
Small, 8(23), 3655-3663 (2012)
Aggregation-induced red-NIR emission organic nanoparticles as effective and photostable fluorescent probes for bioimaging
Zhao Q, et al.
Journal of Materials Chemistry, 22(30), 15128-15135 (2012)
Linhua Zhang et al.
International journal of nanomedicine, 10, 2101-2114 (2015-04-07)
The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a
Junlong Geng et al.
Small (Weinheim an der Bergstrasse, Germany), 8(23), 3655-3663 (2012-08-16)
Folate functionalized nanoparticles (NPs) that contain fluorogens with aggregation-induced emission (AIE) characteristics are fabricated to show bright far-red/near-infrared fluorescence, a large two-photon absorption cross section and low cytotoxicity, which are internalized into MCF-7 cancer cells mainly through caveolae-mediated endocytosis. One-photon
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