880124X
Avanti
DSPE-PEG(2000) Folate
Avanti Research™ - A Croda Brand
别名:
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt):methanol (9:1)
产品名称
DSPE-PEG(2000) Folate, Avanti Research™ - A Croda Brand
方案
>99% (TLC)
表单
liquid
包装
pkg of 1 × 1 mL (880124X-10mg)
pkg of 1 × 1 mL (880124X-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
浓度
1 mg/mL (880124X-1mg)
10 mg/mL (880124X-10mg)
运输
dry ice
储存温度
−20°C
一般描述
DSPE-PEG(2000) Folate, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000], is a functionalized PEG lipid. This lipid is added into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for numerous solid tumors and myeloid leukemias. Folate targeted drug delivery is used an effective therapy for the treatment and imaging of various cancers and inflammatory diseases. Folate conjugates with low molecular weight and high binding affinity for folate receptors (FR) on cell surface deliver a variety of molecular complexes such as protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents to pathologic cells without affecting normal tissues.
应用
DSPE-PEG(2000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000]) may be used in preparation of folate-conjugated liposomes and folate-modified microvesicles (MVs).
包装
5 mL Clear Glass Sealed Ampule (880124X-10mg)
5 mL Clear Glass Sealed Ampule (880124X-1mg)
制备说明
Soluble in ethanol, DMSO, and Chloroform:Methanol:Ammonia (80:20:2) at 5mg/mL
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
警示用语：
Danger
危险分类
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 2 - STOT SE 3
靶器官
Eyes,Central nervous system, Liver,Kidney, Respiratory system
储存分类代码
3 - Flammable liquids
WGK
WGK 3
闪点(°F)
80.6 °F
闪点(°C)
27 °C
法规信息
危险化学品
易制毒化学品（2类）
此项目有
Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation
Deng W, et al.
Nature Communications, 9(1) (2018)
Wei Deng et al.
Nature communications, 9(1), 2713-2713 (2018-07-15)
Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes
Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles
Zhang W, et al.
ACS Nano, 11(1), 277-290 (2017)
Andrew R Hilgenbrink et al.
Journal of pharmaceutical sciences, 94(10), 2135-2146 (2005-09-02)
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjugates have
Wei Zhang et al.
ACS nano, 11(1), 277-290 (2016-12-23)
Cell-derived microvesicles (MVs), which are biogenic nanosized membrane-bound vesicles that convey bioactive molecules between cells, have recently received attention for use as natural therapeutic platforms. However, the medical applications of MV-based delivery platforms are limited by the lack of effective
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