产品名称
PMA, Avanti Research™ - A Croda Brand
InChI
1S/C21H40NO6S.ClH/c1-8-9-12-27-19(24)17(2)15-21(3,16-29-14-10-18(23)26-7)20(25)28-13-11-22(4,5)6;/h17H,8-16H2,1-7H3;1H/q+1;/p-1
InChI key
OEHGLUZNEWMIMQ-UHFFFAOYSA-M
SMILES string
C[N+](C)(C)CCOC(C(C)(CC(C)([H])C(OCCCC)=O)CSCCC(OC)=O)=O.[Cl-]
assay
99% (NMR)
form
powder
packaging
pkg of 1 × 100 mg (880134P-100mg)
pkg of 1 × 500 mg (880134P-500mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
PMA（聚甲基丙烯酸酯）通过脂质双层的碎片化或溶解自发形成纳米圆盘。它用于设计可形成纳米圆盘的聚合物，以模拟蛋白质和肽的两亲性质。PMA N−C4−60−高效地溶解脂质膜并与 1,2-二肉豆蔻酰-sn-甘油-3-磷酸胆碱（DMPC）形成脂质纳米圆盘。PMA N−C4−60−4.7的加入降低了大肠杆菌悬浮液的光散射强度。
General description
PMA（聚甲基丙烯酸酯）无规共聚物是两亲性的，由疏水性和亲水性侧链组成。
Packaging
20mL 透明螺旋盖玻璃小瓶（880134P-500mg）
5mL 琥珀色螺旋盖玻璃小瓶（880134P-100mg）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Spontaneous lipid nanodisc fomation by amphiphilic polymethacrylate copolymers
Yasuhara K, et al.
Journal of the American Chemical Society, 139(51), 18657-18663 (2017)
Juan Francisco Bada Juarez et al.
Chemistry and physics of lipids, 221, 167-175 (2019-04-04)
Nanoparticles assembled with poly(styrene-maleic acid) copolymers, identified in the literature as Lipodisq, SMALPs or Native Nanodisc, are routinely used as membrane mimetics to stabilise protein structures in their native conformation. To date, transmembrane proteins of varying complexity (up to 8
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