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Merck
CN

880230C

Avanti

18:1 PEG5000 PE

Avanti Research™ - A Croda Brand

别名:

1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000] (ammonium salt)

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关于此项目

化学文摘社编号:
474922-90-2
MDL编号:
MFCD02262251
UNSPSC代码:
12352211
NACRES:
NA.25

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产品名称

18:1 PEG5000 PE, Avanti Research™ - A Croda Brand 880230C

方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2.5 mL (880230C-25mg)
pkg of 2 × 4 mL (880230C-200mg)

制造商/商品名称

Avanti Research™ - A Croda Brand 880230C

浓度

10 mg/mL (880230C-25mg)
25 mg/mL (880230C-200mg)

运输

dry ice

储存温度

−20°C

SMILES字符串

[H][C@@](COP([O-])(OCCNC([(OCH2CH2)113OCH3])=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]

相关类别

应用

18:1 PEG5000 PE or 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000 has been used in small unilamellar vesicles (SUV).

生化/生理作用

18:1 PEG5000 PE, also known as 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000], is used along with lipid modified dendrimer copolymer to co-deliver siRNA and drugs to tumors.

包装

5 mL Clear Glass Sealed Ampule (880230C-200mg)
5 mL Clear Glass Sealed Ampule (880230C-25mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

靶器官

Liver,Kidney, Respiratory system

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

危险化学品
易制毒化学品（2类）
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Reconstitution of TCR signaling using supported lipid bilayers
Su X, et al.
Methods in Molecular Biology (2017)
Xiaolei Su et al.
Methods in molecular biology (Clifton, N.J.), 1584, 65-76 (2017-03-04)
Biochemical reconstitution has served as an important tool for understanding the mechanisms of many cellular processes including DNA replication, transcription, translation, vesicle trafficking, and ubiquitin-mediated proteolysis. Here, we demonstrate that biochemical reconstitution can be applied to studying a complex signaling
TCR--pMHC bond conformation controls TCR ligand discrimination
Sasmal DK, et al.
Cellular & Molecular Immunology, 65-76 (2017)
Dibyendu K Sasmal et al.
Cellular & molecular immunology, 17(3), 203-217 (2019-09-19)
A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface. Here, we used in situ fluorescence resonance energy transfer (FRET) to measure the distances of single TCR-pMHC bonds and the conformations of
Jiayi Pan et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 136, 18-28 (2019-01-12)
Multidrug resistance (MDR) significantly decreases the therapeutic efficiency of anti-cancer drugs. Its reversal could serve as a potential method to restore the chemotherapeutic efficiency. Downregulation of MDR-related proteins with a small interfering RNA (siRNA) is a promising way to reverse
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