880430O
Avanti
18:1 PEG350 PE
Avanti Research™ - A Croda Brand
别名:
1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-350] (ammonium salt)
Product Name
18:1 PEG350 PE, Avanti Research™ - A Croda Brand 880430O
表单
liquid
包装
pkg of 1 × 25 mg (880430O-25mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 880430O
运输
dry ice
储存温度
−20°C
SMILES字符串
[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[NH4+]
InChI
1S/C57H108NO17P.H3N/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-55(59)72-52-54(75-56(60)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2)53-74-76(62,63)73-37-36-58-57(61)71-51-50-70-49-48-69-47-46-68-45-44-67-43-42-66-41-40-65-39-38-64-3;/h18-21,54H,4-1
InChI key
JIOGNAWOCNOXPY-VYAKHVMVSA-N
一般描述
18:0 PEG350 PE is a polyethylene glycol (PEG) conjugated phospholipid. PEGylated phospholipids are amphiphilic polymers, The molecular weight and exact mass are averages based on the polydispersity of PEG.
应用
18:1 PEG350 PE is suitable for use:
- in the preparation of lipid bilayer membranes to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA63)
- to prepare Gd-C5F12-phospholipid nanobubbles
- to form aqueous dispersions and to study metal cation induced cubic phase
生化/生理作用
Polyethylene glycol (PEG) conjugated phospholipids are known to protect the steric nature of liposomes. Hence, they are commonly recommended for use in liposome formulation. PEGylated lipids are used as drug carriers. Use of highly concentrated PEG-lipids makes the possibility of mixed micelles.
包装
5 mL Clear Glass Sealed Ampule (880430O-25mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
10 - Combustible liquids
WGK
WGK 3
Micro- and Nanoengineering of the Cell Surface (2014)
Michela Pisani et al.
The journal of physical chemistry. B, 112(17), 5276-5278 (2008-04-11)
Metal cations (Mn(2+) or Ca(2+)) in aqueous dispersions of mixtures of dioleoylphosphatidylethanolamine (DOPE) and poly(ethylene glycol)-functionalized DOPE (DOPE-PEG(350)) induce, above a certain amount of the PEG lipid component, a phase transition from the inverted hexagonal phase H(II) to the bicontinuous
Se-Young Choi et al.
PloS one, 7(3), e34333-e34333 (2012-04-06)
To develop a long-circulating theragnostics, meaning therapeutics and diagnostics for MR-guided HIFU ablation, we designed and prepared Gd-C(5)F(12)-phospholipid nanobubbles (PLNs) 30-100 nm in diameter. The biochemical and physical characterization of Gd-C(5)F(12)-PLNs were performed. Since Gd-C(5)F(12)-PLN-50 (Φ = 50 nm) and Gd-C(5)F(12)-PLN-100 (Φ = 100
Sirkku Hanski et al.
Biomacromolecules, 11(12), 3440-3447 (2010-10-27)
We report on highly ordered oblique self-assemblies in ionic complexes of PEGylated triple-tail lipids and cationic polypeptides, as directed by side-chain crystallization, demonstrating also reversible oblique-to-hexagonal order-order transitions upon melting of the side chains. This is achieved in bulk by
G F Peacock et al.
Drug delivery, 10(1), 29-34 (2003-01-30)
A new cholesterol-carborane conjugate (BCH) has been synthesized as a potential targeting agent for boron neutron capture therapy (BNCT) of cancers. The compound is extremely water insoluble and was formulated in two liposomal formulations to determine if the compound could
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