产品名称
18:0 PEG1000 PE, Avanti Research™ - A Croda Brand 880720P, powder
InChI
1S/C87H172NO32P.H3N/c1-4-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-85(89)117-82-84(120-86(90)35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-5-2)83-119-121(92,93)118-37-36-88-87(91)116-81-80-115-79-78-114-77-76-113-75-74-112-73-72-111-71-70-110-69-68-109-67-6
InChI key
RMRFKOYDUNAYRA-NHGDJFPISA-N
SMILES string
[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 200 mg (880720P-200mg)
pkg of 1 × 25 mg (880720P-25mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 880720P
shipped in
dry ice
storage temp.
−20°C
Application
1,2-二硬脂酰-sn-甘油-3-磷酸乙醇胺-N-[甲氧基(聚乙二醇)-1000](18:0 PEG1000 PE)可用于制备空间稳定脂质体,并通过小角度X线检查散射(SAXS)法研究其特性。它也适用于无胆固醇的聚乙二醇化(CF-PEG)脂质体,以研究其在装载亲水性药物卡铂时的长期稳定性。
Biochem/physiol Actions
磷脂乙醇胺(PE)是细胞膜上几种磷脂的底物。它与磷脂周转有关。PE也被发现可以阻止肿瘤进展。
General description
分子量和精确质量是基于聚乙二醇(PEG)的多分散性的平均值。
Packaging
5 mL棕色玻璃螺旋盖小瓶(880720P-200mg)
5 mL棕色玻璃螺旋盖小瓶(880720P-25mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
Z Varga et al.
Chemistry and physics of lipids, 165(4), 387-392 (2012-01-10)
Synchrotron small-angle X-ray scattering analysis of the bilayer structure of a pharmacologically relevant sterically stabilized liposome system is presented. Describing the electron density profile of the bilayer with the superposition of Gaussian functions, the contribution of the poly(ethylene glycol) (PEG)
Anumita Chaudhury et al.
International journal of pharmaceutics, 430(1-2), 167-175 (2012-04-28)
The obstacles in translating liposome formulations into marketable products could be attributed to their physical instabilities upon long-term storage as aqueous dispersions. Lyophilization is the most commonly used technique to improve physical stability of liposomes. The development of stable, lyophilized
Adilson Kleber Ferreira et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 67(6), 481-487 (2013-06-19)
Phosphoethanolamine (Pho-s) is a compound involved in phospholipid turnover, acting as a substrate for many phospholipids of the cell membranes. In a recent study, we showed that Pho-s has antitumor effect in the several tumor cells. In this study we
Brian J Nablo et al.
Biophysical journal, 95(3), 1157-1164 (2008-07-23)
Nonelectrolyte polymers of poly(ethylene glycol) (PEG) were used to estimate the diameter of the ion channel formed by the Bacillus anthracis protective antigen 63 (PA(63)). Based on the ability of different molecular weight PEGs to partition into the pore and
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