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关于此项目
经验公式（希尔记法）:
C59H116Cl5N7O4
化学文摘社编号:
分子量:
1164.86
MDL number:
UNSPSC Code:
12352211
NACRES:
NA.25
产品名称
MVL5, Avanti Research™ - A Croda Brand 890000P, powder
assay
>99% (TLC)
form
powder
packaging
package of 1 × 1 mg (890000P-1mg), package of 1 × 5 mg (890000P-5MG)
manufacturer/tradename
Avanti Research™ - A Croda Brand 890000P
application(s)
advanced drug delivery
lipid type
transfection
cationic lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCC/C=C\CCCCCCCCOC1=C(OCCCCCCCC/C=C\CCCCCCCC)C=C(C(NCCNC(C([NH2+]CCC[NH3+])CCC[N+](CCC[NH3+])([H])CCC[NH3+])=O)=O)C=C1.[5Cl-]
Application
MVL5已用于脂质体制备。
Biochem/physiol Actions
MVL5是阳离子脂质，是五价分子。它与脂质体制剂中的1，2-二油酰基-sn-甘油-3-乙基磷酸胆碱（DOPC）结合使用，以实现有效的基因转染。认为其毒性较小。
Packaging
5 mL棕色玻璃螺旋盖小瓶（890000P-1MG）
5 mL棕色玻璃螺旋盖小瓶（890000P-5MG）
5 mL棕色玻璃螺旋盖小瓶（890000P-5MG）
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available
Nathan F Bouxsein et al.
Biochemistry, 46(16), 4785-4792 (2007-03-30)
Small interfering RNAs (siRNAs) of 19-25 bp mediate the cleavage of complementary mRNA, leading to post-transcriptional gene silencing. We examined cationic lipid (CL)-mediated delivery of siRNA into mammalian cells and made comparisons to CL-based DNA delivery. The effect of lipid
Cecília Leal et al.
Langmuir : the ACS journal of surfaces and colloids, 27(12), 7691-7697 (2011-05-27)
The self-assembly of a custom-synthesized pentavalent cationic lipid (MVL5) and glycerol monooleate (GMO) with small interfering RNA (siRNA) results in the formation of a double-gyroid bicontinuous inverted cubic phase with colocalized lipid/siRNA domains as shown by synchrotron X-ray scattering and
Kai Ewert et al.
Journal of medicinal chemistry, 45(23), 5023-5029 (2002-11-01)
Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. This paper describes the efficient and facile synthesis and the characterization of a new multivalent cationic lipid with a double-branched headgroup structure for
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 890000P-5MG | 04065266440850 |
| 890000P-1MG | 04061835188260 |