Merck
CN

890703P

Avanti

18:0 EPC (Cl Salt)

Avanti Polar Lipids 890703P, powder

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别名:
1,2-distearoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
经验公式(希尔记法):
C46H93NO8PCl
分子量:
854.66
NACRES:
NA.25

形式

powder

包装

pkg of 1 × 25 mg (890703P-25mg)

制造商/商品名称

Avanti Polar Lipids 890703P

脂质类型

transfection
cationic lipids

运输

dry ice

储存温度

−20°C

SMILES字符串

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O)OCC.[Cl-]

应用

1,2-distearoyl-sn-glycero-3-ethylphosphocholine (18:0 EPC) might be used:
  • to study its effect on the synergistic antimicrobial action of eugenol against Escherichia coli C600
  • to test its use in the formation of lipid nanoparticle variants
  • as a constituent of the microbubble formulation
  • to prepare lipid monolayer for the study on the nature and orientation of interaction between graphene oxide (GO) and lipid models

生化/生理作用

Cationic lipids are useful co-adjuvants for promoting the immunogenicity of vaccines. 1,2-distearoyl-sn-glycero-3-ethylphosphocholine (18:0 EPC) is a cationic lipid and is found to upregulate cluster of differentiation (CD)80 and CD86 co-stimulatory molecules. The hydrophilic moiety and the acyl chains of the cationic lipids highly influences their co-stimulatory action.

包装

5 mL Amber Glass Screw Cap Vial (890703P-25mg)

储存分类代码

11 - Combustible Solids

WGK

WGK 3


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T1503
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25G
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1000309185

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Head groups of lipids govern the interaction and orientation between graphene oxide and lipids
Li S, et al.
The Journal of Physical Chemistry C, 117(31), 16150-16158 (2013)
Caroline Lonez et al.
Advanced drug delivery reviews, 64(15), 1749-1758 (2012-05-29)
Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a
Caroline Lonez et al.
Progress in lipid research, 47(5), 340-347 (2008-04-22)
Cationic lipids are positively charged amphiphilic molecules which, for most of them, form positively charged liposomes, sometimes in combination with a neutral helper lipid. Such liposomes are mainly used as efficient DNA, RNA or protein carriers for gene therapy or
Jurriaan J J Gillissen et al.
Langmuir : the ACS journal of surfaces and colloids, 34(1), 503-511 (2017-12-05)
Enclosed lipid bilayer structures, referred to as liposomes or lipid vesicles, have a wide range of biological functions, such as cellular signaling and membrane trafficking. The efficiency of cellular uptake of liposomes, a key step in many of these functions
Haoshu Zhang et al.
Applied and environmental microbiology, 83(21) (2017-08-27)
In this study, the effect of individual lecithin phospholipids on the antimicrobial properties of eugenol against Escherichia coli C600 was investigated. We tested five major phospholipids common in soy or egg lecithin (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine [DPPC], 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine [DSPC], 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine [DPPE], 1,2-dihexadecanoyl-sn-glycero-3-phosphate [sodium

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