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安全信息

890704C

Avanti

18:1 EPC (Cl Salt)

Avanti Polar Lipids 890704C

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别名:
1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
经验公式（希尔记法）:
C46H89NO8PCl
CAS号:
474945-24-9
分子量:
850.63
NACRES:
NA.25

形式

liquid

包装

pkg of 1 × 2.5 mL (890704C-25mg)
pkg of 1 × 4 mL (890704C-100mg)
pkg of 2 × 4 mL (890704C-200mg)

制造商/商品名称

Avanti Polar Lipids 890704C

浓度

10 mg/mL (890704C-25mg)
25 mg/mL (890704C-100mg)
25 mg/mL (890704C-200mg)

脂质类型

transfection
cationic lipids

运输

dry ice

储存温度

−20°C

SMILES字符串

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)OCC.[Cl-]

一般描述

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (18:1 EPC) is a cationic alkylated phospholipid.

应用

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (18:1 EPC (Cl Salt)) is suitable:
  • for composing lipid shell to prepare lipopolyplex/mRNA vaccine
  • in solvent-assisted preparation of supported lipid bilayers
  • along with 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) in mixed liposomes as colloidal vectors for physicochemical study of the DNA compaction
  • to formulate the lipid nanoparticle (LNP1) to enhance intracellular delivery mediated by shock waves

生化/生理作用

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (18:1 EPC) serves as a transfection reagent. 18:1 EPC is applicable in liposomes and lipoplexes. It is a potential vector in gene therapy.

包装

5 mL Clear Glass Sealed Ampule (890704C-100mg)
5 mL Clear Glass Sealed Ampule (890704C-200mg)
5 mL Clear Glass Sealed Ampule (890704C-25mg)

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

does not flash

闪点(°C)

does not flash

法规信息

易制毒化学品（2类）
危险化学品

分析证书(COA)

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示例

T1503
货号
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包装规格/数量

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705578-5MG-PW

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1000309185

输入内容 1.000309185)

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索取COA

Gene vectors based on DOEPC/DOPE mixed cationic liposomes: a physicochemical study
Munoz U, et al.
Soft Matter, 7(13), 5991-6004 (2011)
Stefano Persano et al.
Biomaterials, 125, 81-89 (2017-02-24)
mRNA-based vaccines have the benefit of triggering robust anti-cancer immunity without the potential danger of genome integration from DNA vaccines or the limitation of antigen selection from peptide vaccines. Yet, a conventional mRNA vaccine comprising of condensed mRNA molecules in
Kabir H Biswas et al.
Langmuir : the ACS journal of surfaces and colloids, 34(4), 1775-1782 (2017-12-28)
The pathway of vesicle adsorption onto a solid support depends on the material composition of the underlying support, and there is significant interest in developing material-independent strategies to modulate the spectrum of vesicle-substrate interactions on a particular surface. Herein, using
Abdul Rahim Ferhan et al.
Nature protocols, 14(7), 2091-2118 (2019-06-09)
The supported lipid bilayer (SLB) platform is a popular cell membrane mimic that is utilized in the chemical, biological, materials science, and medical fields. To date, SLB preparation has proven challenging because of the need for specialized fabrication equipment, domain-specific
Jing Zhang et al.
ACS applied materials & interfaces, 11(11), 10481-10491 (2019-02-23)
Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical translation of macrodrug-based therapies. Encapsulation of macromolecules in lipid nanoparticles (LNPs) can protect
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