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Merck
CN

890890C

Avanti

18:1 TAP (DOTAP)

Avanti Research™ - A Croda Brand

别名:

1,2-二油酰基-3-三甲基铵-丙烷 (氯盐)

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关于此项目

经验公式（希尔记法）:
C42H80NO4Cl
化学文摘社编号:
132172-61-3
分子量:
698.54
MDL编号:
MFCD01310872
UNSPSC代码:
12352211
NACRES:
NA.25

主要文件

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方案

>99% (TLC)

表单

liquid

包装

pkg of 1 × 2.5 mL (890890C-25mg)
pkg of 2 × 20 mL (890890C-1g)
pkg of 2 × 4 mL (890890C-200mg)
pkg of 5 × 4 mL (890890C-500mg)

制造商/商品名称

Avanti Research™ - A Croda Brand

浓度

10 mg/mL (890890C-25mg)
25 mg/mL (890890C-1g)
25 mg/mL (890890C-200mg)
25 mg/mL (890890C-500mg)

应用

advanced drug delivery

脂质类型

cationic lipids
transfection

运输

dry ice

储存温度

−20°C

SMILES字符串

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChI key

KSXTUUUQYQYKCR-LQDDAWAPSA-M

相关类别

应用

18:1 TAP (DOTAP) 已用于制备脂质体支持的双层。

生化/生理作用

18:1 TAP (DOTAP) 为阳离子脂质结构，用于体内和体外核酸和蛋白递送。脂质组成和细胞类型会影响 DOTAP （1,2-二油酰基-3-三甲基铵-丙烷）的转染潜能。18:1 TAP（DOTAP）介导造血干细胞（HSCs）的基因敲低技术。

包装

30 mL 带螺旋盖的琥珀色窄口玻璃瓶（890890C-1g）
5 mL透明玻璃密封安瓿（890890C-200mg）
5 mL透明玻璃密封安瓿（890890C-25mg）
5 mL透明玻璃密封安瓿（890890C-500mg）

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

危险化学品
易制毒化学品（2类）

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
Dengler EC, et al.
J. Controlled Release, 168(2), 209-224 (2013)
Elias J Sayour et al.
Nano letters, 18(10), 6195-6206 (2018-09-28)
Translation of nanoparticles (NPs) into human clinical trials for patients with refractory cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome these limitations, simple well-characterized mRNA lipid-NPs have been developed as cancer immunotherapeutic vaccines. While
Hojun Kim et al.
ACS nano, 12(9), 9196-9205 (2018-08-08)
The success of gene technologies hinges on our ability to engineer superior encapsulation and delivery vectors. Cubosomes are lipid-based nanoparticles where membranes, instead of enveloping into classic liposomes, intertwine into complex arrays of pores well-ordered in a cubic lattice. These
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