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Merck
CN

890890C

Avanti

18:1 TAP (DOTAP)

Avanti Research™ - A Croda Brand

别名:

1,2-二油酰基-3-三甲基铵-丙烷 (氯盐)

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关于此项目

经验公式（希尔记法）:
C42H80NO4Cl
化学文摘社编号:
132172-61-3
分子量:
698.54
MDL number:
MFCD01310872
UNSPSC Code:
12352211
NACRES:
NA.25

主要文件

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产品名称

18:1 TAP (DOTAP), Avanti Research™ - A Croda Brand

SMILES string

[H]C(C[N+](C)(C)C)(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O.[Cl-]

InChI

1S/C42H80NO4.ClH/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-41(44)46-39-40(38-43(3,4)5)47-42(45)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2;/h20-23,40H,6-19,24-39H2,1-5H3;1H/q+1;/p-1/b22-20-,23-21-;

InChI key

KSXTUUUQYQYKCR-LQDDAWAPSA-M

assay

>99% (TLC)

form

liquid

packaging

pkg of 1 × 2.5 mL (890890C-25mg)
pkg of 2 × 20 mL (890890C-1g)
pkg of 2 × 4 mL (890890C-200mg)
pkg of 5 × 4 mL (890890C-500mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

concentration

10 mg/mL (890890C-25mg)
25 mg/mL (890890C-1g)
25 mg/mL (890890C-200mg)
25 mg/mL (890890C-500mg)

application(s)

advanced drug delivery

lipid type

cationic lipids
transfection

shipped in

dry ice

storage temp.

−20°C

相关类别

Application

18:1 TAP (DOTAP) 已用于制备脂质体支持的双层。

Biochem/physiol Actions

18:1 TAP (DOTAP) 为阳离子脂质结构，用于体内和体外核酸和蛋白递送。脂质组成和细胞类型会影响 DOTAP （1,2-二油酰基-3-三甲基铵-丙烷）的转染潜能。18:1 TAP（DOTAP）介导造血干细胞（HSCs）的基因敲低技术。

Packaging

30 mL 带螺旋盖的琥珀色窄口玻璃瓶（890890C-1g）
5 mL透明玻璃密封安瓿（890890C-200mg）
5 mL透明玻璃密封安瓿（890890C-25mg）
5 mL透明玻璃密封安瓿（890890C-500mg）

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

危险化学品
易制毒化学品（2类）
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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DOTAP (and other cationic lipids): chemistry, biophysics, and transfection
Simberg D, et al.
Critical Reviews in Therapeutic Drug Carrier Systems, 21(4) (2004)
Efficient siRNA delivery by the cationic liposome DOTAP in human hematopoietic stem cells differentiating into dendritic cells
Martino S, et al.
BioMed Research International, 2009 (2009)
Mesoporous silica-supported lipid bilayers (protocells) for DNA cargo delivery to the spinal cord
Dengler EC, et al.
J. Controlled Release, 168(2), 209-224 (2013)
Xuejuan Ma et al.
Langmuir : the ACS journal of surfaces and colloids, 35(49), 16304-16311 (2019-11-09)
Aggregation-induced emission (AIE) is a powerful method to produce fluorescence for a diverse range of applications. While most previous work induced aggregation by change of solvent, ionic strength, pH, or self-assembly, we herein explored adsorption-induced aggregation using 4,4'-(hydrazine-1,2-diylidene bis(methanylylidene)) bis(3-hydroxybenzoic
Elias J Sayour et al.
Nano letters, 18(10), 6195-6206 (2018-09-28)
Translation of nanoparticles (NPs) into human clinical trials for patients with refractory cancers has lagged due to unknown biologic reactivities of novel NP designs. To overcome these limitations, simple well-characterized mRNA lipid-NPs have been developed as cancer immunotherapeutic vaccines. While
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