assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 5 mg (890893P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand
application(s)
vaccine development
lipid type
transfection
cationic lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CC1(CC[C@H](OC(N(CCCN)CCCCNCCCN)=O)C2)C2=CCC3C1CCC4(C)C3CCC4C(CCCC(C)C)C
InChI
1S/C38H70N4O2/c1-28(2)11-8-12-29(3)33-15-16-34-32-14-13-30-27-31(17-19-37(30,4)35(32)18-20-38(33,34)5)44-36(43)42(26-10-22-40)25-7-6-23-41-24-9-21-39/h13,28-29,31-35,41H,6-12,14-27,39-40H2,1-5H3/t29?,31-,32?,33?,34?,35?,37?,38?/m0/s1
InChI key
KBBLYWGVXTZWCU-JPEXWTJSSA-N
General description
N4-Cholesteryl-Spermine (GL67) comprises of the cationic lipid GL67 with spermine and cholesterol.
Application
- GL67 lipid-based liposomal formulation for efficient siRNA delivery into human lung cancer cells.: This study explores the use of GL67 liposomes for delivering siRNA to human lung cancer cells, highlighting its potential for targeted cancer therapies (Jarallah et al., 2023).
- Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes.: The research focuses on the efficacy of GL67 liposomes in aerosol form for non-viral gene therapy in the lungs, demonstrating significant gene transfer efficiency (Le Gall et al., 2021).
- Low-frequency ultrasound increases non-viral gene transfer to the mouse lung.: The study investigates the enhancement of GL67-mediated gene transfer using low-frequency ultrasound, showing improved transfection in mouse lungs (Xenariou et al., 2010).
Biochem/physiol Actions
N4-Cholesteryl-Spermine (GL67) in combination with DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DMPE-PEG5000 (1,2-Dimyristoyl-sn-Glycero-3-Phosphoethanolamine-N-[methoxy (Polyethylene glycol)5000] is used as a non-viral gene transfer agent.
Packaging
5 mL Amber Glass Screw Cap Vial (890893P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
No data available
flash_point_c
No data available