900407P
Avanti
16:0-pacFA PC
Avanti Research™ - A Croda Brand
别名:
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine
产品名称
16:0-pacFA PC, Avanti Research™ - A Croda Brand 900407P, powder
方案
>99% (TLC)
表单
powder
包装
pkg of 1x10 mg (900407P-10MG)
pkg of 1 × 1 mg (900407P-1mg)
制造商/商品名称
Avanti Research™ - A Croda Brand 900407P
脂质类型
click reagents
phospholipids
运输
dry ice
储存温度
−20°C
SMILES字符串
C#CCCCC1(N=N1)CCCCCCCCC(O[C@](COP([O-])(OCC[N+](C)(C)C)=O)([H])COC(CCCCCCCCCCCCCCC)=O)=O
InChI
1S/C39H72N3O8P/c1-6-8-10-11-12-13-14-15-16-17-18-21-24-28-37(43)47-34-36(35-49-51(45,46)48-33-32-42(3,4)5)50-38(44)29-25-22-19-20-23-27-31-39(40-41-39)30-26-9-7-2/h2,36H,6,8-35H2,1,3-5H3/t36-/m1/s1
InChI key
XBLDRLHMTZEHJM-PSXMRANNSA-N
一般描述
The pacFA lipid attached to 1-palmitoyl-sn-glycero-3-phosphocholine, contains a photoactivable diazirine ring with a clickable alkyne group.
应用
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) might be used to label hydrogenated zwitterionic bicelles (HZB) and hydrogenated anionic bicelles (HAB).
生化/生理作用
1-palmitoyl-2-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-sn-glycero-3-phosphocholine (16:0-pacFA PC) may be used for a global analysis of protein–lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.
包装
5 mL Amber Glass Screw Cap Vial (900407P-10MG)
5 mL Amber Glass Screw Cap Vial (900407P-1mg)
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
储存分类代码
11 - Combustible Solids
闪点(°F)
No data available
闪点(°C)
No data available
Raphael Dos Santos Morais et al.
Biophysical journal, 115(7), 1231-1239 (2018-09-11)
Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells. Among them, dystrophin strengthens the sarcolemma through protein-lipid interactions, and its absence due to gene mutations leads to the severe Duchenne muscular dystrophy. Most of the
Dominique Mias-Lucquin et al.
Journal of structural biology, 209(1), 107411-107411 (2019-11-07)
Dystrophin is a large intracellular protein that prevents sarcolemmal ruptures by providing a mechanical link between the intracellular actin cytoskeleton and the transmembrane dystroglycan complex. Dystrophin deficiency leads to the severe muscle wasting disease Duchenne Muscular Dystrophy and the milder
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Per Haberkant et al.
Angewandte Chemie (International ed. in English), 52(14), 4033-4038 (2013-03-02)
Per Haberkant et al.
Biochimica et biophysica acta, 1841(8), 1022-1030 (2014-01-21)
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as
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