产品名称
pacFA-18:1 PC, Avanti Research™ - A Croda Brand 900408P, powder
InChI key
MZZDOXWHMLEPLR-FZMBPTIQSA-N
SMILES string
C#CCCCC1(N=N1)CCCCCCCCC(OC[C@@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COP([O-])(OCC[N+](C)(C)C)=O)=O
assay
>99% (TLC)
form
powder
packaging
pkg of 1 × 1 mg (with stopper and crimp cap (900408P-1mg))
manufacturer/tradename
Avanti Research™ - A Croda Brand 900408P
lipid type
click reagents
phospholipids
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
1-(9-(3-pent-4-ynyl-3-H-diazirin-3-yl)-nonanoyl)-2-oleoyl-sn-glycero-3-phosphocholine (pacFA-18:1 PC) may be used for global analysis of protein–lipid interactions in living cells. pacFA acts as a precursor for the biosynthesis of bifunctional lipids. Proteins in contact with the bifunctional lipids are then cross-linked by ultraviolet (UV) irradiation of the diazirine ring. Finally, click chemistry is used to label the alkyne with a reporter molecule.
General description
The pacFA lipid attached to 2-oleoyl-sn-glycero-3-phosphocholine, contains a photoactivable diazirine ring with a clickable alkyne group.
Packaging
2 mL Amber Serum Vial with Stopper and Crimp Cap (900408P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
存储类别
11 - Combustible Solids
flash_point_f
No data available
flash_point_c
No data available
Mathias J Gerl et al.
PloS one, 11(4), e0153009-e0153009 (2016-04-23)
Cell membranes contain hundreds to thousands of individual lipid species that are of structural importance but also specifically interact with proteins. Due to their highly controlled synthesis and role in signaling events sphingolipids are an intensely studied class of lipids.
In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.
Per Haberkant et al.
Angewandte Chemie (International ed. in English), 52(14), 4033-4038 (2013-03-02)
Per Haberkant et al.
Biochimica et biophysica acta, 1841(8), 1022-1030 (2014-01-21)
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as
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