InChI
1S/C17H36NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(19)16(18)15-23-24(20,21)22/h13-14,16-17,19H,2-12,15,18H2,1H3,(H2,20,21,22)/b14-13+/t16-,17+/m0/s1
InChI key
VITGNIYTXHNNNE-LHMZYYNSSA-N
SMILES string
CCCCCCCCCCCC/C=C/[C@@]([H])(O)[C@]([NH3+])([H])COP([O-])(O)=O
assay
>99% (TLC)
form
ethanol solution
packaging
pkg of 1 × 1 mL (LM2144-1EA)
manufacturer/tradename
Avanti Research™ - A Croda Brand
concentration
~10 μg/mL (Refer to C of A for lot specific concentration.)
application(s)
lipidomics
metabolomics
shipped in
dry ice
storage temp.
−20°C
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General description
Sphingosine-1-phosphate (S1P) is a sphingolipid found in yeast, plants and mammals and is produced in endothelial cells. It is a cellular metabolite and signalling lipid in mammalian cells. S1P is synthesized by sphingosine kinases from sphingosine. It is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1-5).
Biochem/physiol Actions
Sphingosine 1-phosphate (S1P) plays a vital role as a secondary messenger in physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes. S1P regulates skin dendritic cells and keratinocytes
Packaging
2 mL Amber Glass Sealed Ampule (LM2144-1EA)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Disclaimer
Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2
存储类别
3 - Flammable liquids
wgk
WGK 1
flash_point_f
55.4 °F - closed cup
flash_point_c
13.0 °C - closed cup
法规信息
危险化学品
此项目有
High-Throughput Assays to Measure Intracellular Ca2+ Mobilization in Cells that Express Recombinant S1P Receptor Subtypes
Valentine WJ and Tigyi G
Methods in Molecular Biology, 77-87 (2012)
Sphingosine-1-phosphate signaling and its role in disease
Maceyka M, et al.
Trends in Cell Biology, 22(1), 50-60 (2012)
Sphingosine-1-phosphate as signaling molecule in the skin
Japtok L, et al.
Allergo journal international, 23(2), 54-59 (2014)
Sphingosine-1-phosphate: an enigmatic signalling lipid
Spiegel S and Milstien S
Nature Reviews in Molecular and Cell Biology, 4(5), 397-397 (2003)
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