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Merck
CN

D-907

地西泮标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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关于此项目

经验公式(希尔记法):
C16H13ClN2O
化学文摘社编号:
分子量:
284.74
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
200-659-6
MDL number:
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grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet, kontrollierte Droge in Deutschland

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

-10 to -25°C

SMILES string

CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13

InChI

1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key

AAOVKJBEBIDNHE-UHFFFAOYSA-N

General description

该认证加标溶液® 适用于通过 HPLC、GC/MS 或 LC-MS/MS 法测试地西泮,从而用于法医分析、临床毒理学、尿液药物测试和大麻效力或杂质分析测试等应用。

地西泮是一种抗焦虑的苯二氮卓类药物,通常用于治疗焦虑症、肌肉痉挛和急性癫痫发作等。

Application

该认证标准物质(CRM)还可作如下用途:
  • 基于富勒烯功能化碳纳米管和离子液体修饰电极(C60-CNTs/IL)以电化学方式测定血清、尿液和片剂中的地西泮
  • 使用铋修饰的预处理铅笔石墨电极(BiPPGE)以差分伏安法分析地西泮片剂和人尿样品
  • 通过直接电子电离-液相色谱-串联质谱(EI-LC-MS/MS)法同时定量测定酒精饮料样品中的安定和氟硝西泮
  • 使用分散纳米材料-超声辅助-微萃取(DNUM)从尿液和血浆样品中提取地西泮和氯二氮环氧化物,并通过高效液相色谱-紫外(HPLC-UV)检测定量
  • 通过固相萃取后跟 LC-MS/MS 法测定对人口服液中安定及其代谢物进行多残留分析

Features and Benefits

  • 完全符合 ISO/IEC 17025 和 ISO 17034 认证
  • 附综合分析证书(CoA),包括稳定性、均匀性、浓度准确性、不确定性和可追溯性数据
  • 通过实时稳定性研究严格测试,以确保准确性和保质期
  • 使用合格的精密天平进行重量准备,以确保最小不确定性
  • 氩气环境下火焰密封,装入安瓿以便长期保存
  • 提供方便的 DEA 豁免格式,以提高实验室效率

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.


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signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

法规信息

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商品

Comparative analysis of Supel™ BioSPME 96-Pin device with a rapid equilibrium dialysis technique for accuracy of measured values, sample cleanliness, and workflow time in drug protein binding.

The application note describes a comparative analysis of plasma protein binding results for free/bound drugs using two different sample extraction steps, with and without agitation.


Voltammetric determination of diazepam using a bismuth modified pencil graphite electrode
Dehghanzade M and Alipour E
Analytical Methods : Advancing Methods and Applications, 8, 1995-2004 (2016)
Electrochemical determination of diazepam in real samples based on fullerene-functionalized carbon nanotubes/ionic liquid nanocomposite
Rahimi-Nasrabadi M, et al.
Sensors and Actuators B, Chemical, 240, 125-131 (2017)
A Amiri Pebdani et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1008, 146-155 (2015-12-15)
Benzodiazepines (BDs) are used widely in clinical practice, due to their multiple pharmacological functions. In this study a dispersive nanomaterial-ultrasound assisted- microextraction (DNUM) method followed by high performance liquid chromatography (HPLC) was used for the preconcentration and determination of chlordiazepoxide



全球贸易项目编号

货号GTIN
D-907-1ML04061833557419