推荐产品
等级
certified reference material
形式
liquid
特点
Snap-N-Spike®/Snap-N-Shoot®
包装
ampule of 1 mL
制造商/商品名称
Cerilliant®
浓度
100 μg/mL in methanol
技术
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
应用
clinical testing
clinical testing
格式
single component solution
储存温度
−20°C
SMILES字符串
CC(=O)C1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(O)CC12C
InChI
1S/C21H30O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h10,15-18,24-25H,4-9,11H2,1-3H3/t15-,16-,17-,18+,19-,20-,21-/m0/s1
InChI key
LCZBQMKVFQNSJR-UJPCIWJBSA-N
一般描述
一种新的校准材料，适用于LC/MS在临床和诊断测试以及内分泌学中的应用。通过LC/MS在全血或血清中测量21-脱氧皮质醇，一种在皮质醇形成中的类固醇中间体，用于先天性肾上腺皮质增生（CAH）和其他肾上腺疾病的新生儿筛查。
应用
- Steroid profiling for the diagnosis of congenital adrenal hyperplasia by microbore ultra-performance liquid chromatography-tandem mass spectrometry: This article emphasizes the significance of steroid profiling using advanced chromatography techniques to diagnose congenital adrenal hyperplasia, highlighting the role of 21-Deoxycortisol as a critical marker (Feng D et al., 2023).
- Second-tier Testing for 21-Hydroxylase Deficiency in the Netherlands: A Newborn Screening Pilot Study: This study introduces a second-tier testing protocol involving 21-Deoxycortisol to enhance the screening process for congenital adrenal hyperplasia in newborns, demonstrating its utility in early and accurate diagnosis (Stroek K et al., 2021).
法律信息
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相关产品
产品编号
说明
价格
氢化可的松-D4标准液 CRM 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
11-脱氧皮质醇-D5标准液 CRM, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
17α-羟孕酮-13C3标准液 溶液, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
靶器官
Eyes
储存分类代码
3 - Flammable liquids
WGK
WGK 1
闪点(°F)
49.5 °F - closed cup
闪点(°C)
9.7 °C - closed cup
法规信息
危险化学品
A Milewicz et al.
Endokrynologia Polska, 44(2), 187-193 (1993-01-01)
The study was aimed at evaluation of usefulness of determination of blood serum 21-deoxycortisol concentration for the detection of heterozygous carriers of incomplete block of 21-hydroxylase synthesis leading to adrenal hyperplasia. An earlier observation of the authors that the determination
[21-Deoxycortisol].
Y Okatani
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 2, 444-447 (1995-03-01)
H Blanché et al.
Human genetics, 101(1), 56-60 (1998-01-07)
21-hydroxylase (21-OH) deficiency accounts for the vast majority of nonclassic (NC) forms of congenital adrenal hyperplasia (CAH), and is associated with symptoms detectable either in childhood (precocious puberty) or sometimes only later in adulthood (hirsutism, acne, amenorrhea). While the severe
Simone Cristoni et al.
Rapid communications in mass spectrometry : RCM, 18(1), 77-82 (2003-12-23)
Congenital adrenal hyperplasia (CAH) is an autosomal recessive disorder mainly caused by 21-hydroxylase deficit (21-OHD). Deletions or mutations of the CYP21 gene induce the impairment of glucocorticoid and mineralcorticoid synthesis. 17-Hydroxyprogesterone (17-OHP) is the hormonal marker in patients, but not
Evaluation of cortisol precursors for the diagnosis of pituitary-dependent hypercortisolism in dogs.
N S Sieber-Ruckstuhl et al.
The Veterinary record, 162(21), 673-678 (2008-05-27)
The serum concentrations of cortisol, 17alpha-hydroxypregnenolone, 17alpha-hydroxyprogesterone, 21-deoxycortisol and 11-deoxycortisol were measured in 19 healthy dogs, 15 dogs with pituitary-dependent hypercortisolism (pdh) and eight dogs with other diseases before and one hour after an injection of synthetic adrenocorticotrophic hormone (acth).
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