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经验公式(希尔记法):
C26H28Cl2N4O4
化学文摘社编号:
分子量:
531.43
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
InChI
1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
SMILES string
ClC1=C(C=CC(Cl)=C1)[C@@]2(O[C@@H](COC3=CC=C(N4CCN(C(C)=O)CC4)C=C3)CO2)CN5C=NC=C5
InChI key
XMAYWYJOQHXEEK-ZEQKJWHPSA-N
grade
certified reference material
form
liquid
feature
(Snap-N-Spike®)
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
2.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable, liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
Quality Level
General description
Ketoconazole, sold under trade names such as Nizoral®, Sebizole, Ketomed, and Fungarest, is an antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. Ketoconazole is routinely assigned therapeutic drug monitoring due to its high toxicity and narrow therapeutic range. This Certified Spiking Solution® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of ketoconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Nizoral is a registered trademark of Johnson & Johnson
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
法规信息
危险化学品
此项目有
Aik Jiang Lau et al.
Pharmacological research, 100, 64-72 (2015-08-05)
Pregnane X receptor (PXR; NR1I2) is a member of the superfamily of nuclear receptors that regulates the expression of genes involved in various biological processes, including drug transport and biotransformation. In the present study, we investigated the effect of 3-hydroxyflavone
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