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Merck
CN

03-0162-00

SMC® Human IL-22 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IL-22 in human serum and plasma

别名:

IL-22 Single Molecule Counting Kit, IL-22 ultra-sensitive immunoassay, IL22 immunoassay kit, Interleukin-22 immunoassay kit

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NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments

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technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
serum

UniProt accession no.

Q9GZX6

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

相关类别

General description

Interleukin-22 (IL-22) is a cytokine produced mainly by Th17 cells, as well as by other immune cells such as innate lymphoid cells. It plays a vital role in tissue homeostasis and repair by promoting the survival and proliferation of epithelial cells, particularly in barrier tissues such as the skin and gut. IL-22 is also involved in the immune response to infections and has been implicated in various inflammatory conditions, highlighting its dual role in both protective immunity and pathology.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease

Features and Benefits

  • Leading Sensitivity: The SMC®technology offers unparalleled performance in the quantification of IL-22 in human serum and plasma, ensuring highly precise measurements.
  • Standard ELISA Workflow with Digital Precision: Follows a familiar sandwich immunoassay format with a unique elution step that separates labeled antibodies for digital counting, improving signal-to-noise ratio and assay reproducibility.
  • Advance Inflammation & Mucosal Immunity Studies: IL-22 plays a key role in epithelial barrier function, tissue repair, and host defense. This assay supports research in autoimmune diseases, IBD, psoriasis, and respiratory infections.
  • Generate Reliable, High-Quality Data: Compatible with FemtoQuest™’s advanced optics and Belysa® Curve Fitting Software, ensuring clean, publication-ready results.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 100 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 50-50,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 110% Plasma: 109%
  • Recovery: Serum: 106% Plasma: 94%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although IL-22 was detectable in non-human primate, mouse, feline and canine samples, the assay has not been verified for these species.

Legal Information

BELYSA is a registered trademark of Merck KGaA, Darmstadt, Germany
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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Mahesh Raundhal et al.
Nature immunology, 22(4), 520-529 (2021-03-24)
Patients with myelodysplastic syndromes (MDSs) display severe anemia but the mechanisms underlying this phenotype are incompletely understood. Right open-reading-frame kinase 2 (RIOK2) encodes a protein kinase located at 5q15, a region frequently lost in patients with MDS del(5q). Here we

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