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Merck
CN

03-0183-00

SMC® Human UCHL1 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human UCHL1 in human serum, plasma, and cerebrospinal fluid (CSF)

别名:

Ubiquitin Carboxyl Terminal Hydrolase L1 immunoassay kit, NDGOA immunoassay kit, PARK5 immunoassay kit, PGP9.5 immunoassay kit, SPG79A immunoassay kit, UCH-L1 Single Molecule Counting kit, UCH-L1 ultra-sensitive immunoassay, Ubiquitin Carboxyl Terminal Hydrolase L1 Single Molecule Counting kit

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NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments

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technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
cerebrospinal fluid (CSF)
serum

UniProt accession no.

P09936

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

相关类别

General description

The Ubiquitin C-terminal hydrolase L1 (UCHL1) protein plays a critical role in the ubiquitin-proteasome system, which is essential for protein degradation and turnover in cells. As a deubiquitinating enzyme, UCHL1 removes ubiquitin molecules from proteins, regulating their stability and function. It is predominantly expressed in neurons and is vital for maintaining cellular homeostasis by modulating protein degradation pathways. UCHL1 has been implicated in conditions such as Alzheimer′s disease, Parkinson′s disease, and Huntington′s disease.

Abnormalities in UCHL1 expression or function can lead to the accumulation of misfolded or damaged proteins, contributing to neuronal stress and cell death. Additionally, UCHL1 is associated with neuroinflammation, as its dysregulation can exacerbate inflammatory responses in the brain. Understanding UCHL1′s role in these processes is crucial for developing therapeutic strategies aimed at enhancing protein degradation pathways and mitigating the effects of neurodegeneration and inflammation in neurological disorders.

Application

Neuroscience/Neurological Disorders/Signaling

Features and Benefits

  • Ultrasensitive Measurement: Enables femtogram-level quantification of UCHL1 in serum, plasma, or CSF.
  • Expanded Analytical Range: Improves signal clarity and minimizes background noise, ensuring consistent performance.
  • Streamlined Assay Design: Follows a standard sandwich immunoassay format while delivering enhanced sensitivity for UCHL1 detection.
  • Automation Compatible: Designed for integration with automated liquid handling platforms to reduce manual input and accelerate lab workflows.
  • Dedicated Scientific Support: Supported by experienced field scientists and technical specialists.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 2,600 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 1300-2,000,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 111% Plasma: 100% CSF: 96%
  • Recovery: Serum: 92% Plasma: 93% CSF: 92%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although UCHL1 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, and canine samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

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