03-0190-00
SMC® Human IL-18 High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Human IL-18 in human serum and plasma
别名:
IGIF immunoassay kit, IL-18 Single Molecule Counting Kit, IL-18 ultra-sensitive immunoassay, Interleukin-18 immunoassay kit
产品线
SMC®
用途
kit sufficient for 96 wells
种属反应性
human
制造商/商品名称
SMC®
技术
single molecule counting: suitable
输入
serum
plasma (K2 EDTA)
UniProt登记号
相容性
for use with FemtoQuest™ and SMCxPRO® instruments
运输
wet ice
储存温度
2-8°C
一般描述
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a significant role in the immune response by promoting the activation and proliferation of T cells and natural killer (NK) cells. It is produced by macrophages and dendritic cells and is involved in the regulation of various immune functions, including the production of other cytokines such as interferon-gamma (IFN-γ). IL-18 contributes to the body′s defense against infections and is implicated in the pathogenesis of several inflammatory and autoimmune diseases.
应用
Inflammatory Disease / Immune Response / Autoimmune Disease
生化/生理作用
Although IL-18 was detectable in mouse, rat, and feline samples, the assay has not been verified for these species.
特点和优势
- Ultrasensitive SMC® Technology: Detects IL-18 at femtogram-level concentrations, with a lower limit of quantification (LLOQ) around 90 fg/mL, making it ideal for low-abundance cytokine profiling.
- Wide Dynamic Range: Accurately quantifies IL-18 across a broad concentration spectrum, suitable for both baseline and elevated inflammatory states.
- Track Inflammatory Signaling with Precision: IL-18 plays a key role in innate immunity and inflammasome activation; this kit helps detect subtle shifts in its expression.
- Advance Research in Autoimmune and Infectious Diseases: Ideal for studying IL-18’s role in conditions like rheumatoid arthritis, Crohn’s disease, and viral infections.
包装
96 well assay
分析说明
- Sensitivity: LLOQ 90 fg/mL* (SMCxPRO® Instrument)
- Standard Curve Range: 40-100,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Serum: 92% Plasma: 92%
- Recovery: Serum: 99% Plasma: 95%
Inflammation & ImmunologyInflammatory DiseaseImmune ResponseAutoimmune Disease
法律信息
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
警示用语：
Danger
危险分类
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
法规信息
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相关内容
Use the power of high sensitivity immunology assays with SMC® technology to precisely characterize low-abundant cytokines like those from Th1/Th2 and Th17 cells.
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