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Merck
CN

03-0191-00

SMC® Human IFN-β1 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human IFNβ1 in human serum and plasma

别名:

Interferon β-1 immunoassay kit, Interferon beta-1 Single Molecule Counting Kit, Interferon beta-1 immunoassay kit, Interferon beta-1 ultra-sensitive immunoassay

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NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments

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description

0.07-0.30 pg/mL, refer to CoA for lot-specific LLOQ

technique(s)

single molecule counting: suitable

input

plasma (K2 EDTA)
serum

UniProt accession no.

P01574

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

relevant disease(s)

infectious diseases; autoimmune diseases; neurodegenerative disorders

shipped in

wet ice

storage temp.

2-8°C

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

相关类别

General description

A member of the type I interferon family of glycoprotein second messengers, human Interferon Beta (IFN-ß1) has been associated with antiviral activity as a secreted factor from infected cells that mediates innate immunity in neighboring cells. In addition, IFN-β1 has also been utilized as treatment for Multiple Sclerosis (MS) due to its ability to ameliorate inflammation in the central nervous system in this disease.

Application

Inflammatory Disease / Immune Response / Autoimmune Disease / Neurodegenerative Diseases / Neurodegenerative Medicine / Virology / Infectious Diseases - Viral / Immunological Signaling

Features and Benefits

  • Reveal the First Responders of Immunity: IFN-β1 is a frontline cytokine in antiviral defense; this kit helps you detect its earliest signals.
  • Empower Neuro and Autoimmune Research: Quantify IFN-β1 in studies of multiple sclerosis, lupus, and other inflammatory conditions with confidence.
  • Precision You Can Count On: Built for reproducibility, with tight CVs across operators and days, because your data deserves consistency.
  • Molecular-Level Listening: Detects IFN-β1 at whisper-quiet levels, down to 150 fg/mL, thanks to ultrasensitive SMC® technology.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 150 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 70-170,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 108% Plasma: 108%
  • Recovery: Serum 88% Plasma: 93%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

  • Assay Buffer
  • IFN-β1 Coated Beads
  • Standard Diluent
  • IFN-β1 Detection Antibody
  • IFN-β1 Standard
  • 10X Wash Buffer
  • Buffer D
  • Elution Buffer B
Although IFNβ1 was detectable in non-human primate, rat, mouse, feline, and canine samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

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