03-0196-00
SMC® Human Total α-synuclein High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Human Total α-Synuclein in human serum, plasma, and cerebrospinal fluid (CSF)
别名:
Human α-synuclein, α-synuclein, Human total-α-synuclein, a-synuclein, total-a-synuclein
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NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments
产品名称
SMC® Human Total α-synuclein High Sensitivity Immunoassay Kit,
description
Used for ultrasensitive quantification of Human Total α-Synuclein in human serum, plasma, and cerebrospinal fluid (CSF)
product line
SMC®
usage
kit sufficient for 96 wells
species reactivity
human
technique(s)
single molecule counting: suitable
input
serum
cerebrospinal fluid (CSF)
plasma (K2 EDTA)
UniProt accession no.
compatibility
for use with FemtoQuest™ and SMCxPRO® instruments
shipped in
wet ice
storage temp.
2-8°C
General description
α-Synuclein is a small, soluble protein predominantly found in the presynaptic terminals of neurons. It actively participates in synaptic function by regulating neurotransmitter release and maintaining synaptic integrity. Additionally, α-synuclein influences the dynamics of synaptic vesicles and interacts with various proteins involved in synaptic transmission. In neurological disorders, particularly neurodegenerative diseases like Parkinson′s disease, α-synuclein misfolds and aggregates into insoluble fibrils, forming Lewy bodies. These aggregates disrupt cellular function, leading to neuronal toxicity and death. The accumulation of α-synuclein also triggers neuroinflammation by activating microglial cells, which can further contribute to neurodegeneration.
Application
NeuroscienceNeurological DisordersNeurodegenerative DiseasesSynucleinopathies
Features and Benefits
- Ultra-Sensitive Femtogram Analysis: Achieve exceptionally low detection limits (fg/mL) in serum, plasma and CSF.
- High-Performance Signal Optimization: Reduced background and expanded dynamic range deliveres highly reproducible results.
- Intuitive Assay Workflow: Utilize a familiar sandwich immunoassay protocol with next-generation sensitivity.
- Scalable Automation: Integrate with robotic liquid handling systems to reduce hands on time and improve lab efficiency.
- Expert Technical Support: Get end-to-end support from field scientists and technical support specialists.
Packaging
96 well assay
Analysis Note
- Sensitivity: LLOQ 1,950 fg/mL* (SMCxPRO® Instrument)
- Standard Curve Range: 490-500,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Serum: 113% Plasma: 118% CSF: 102%
- Recovery: Serum: 96% Plasma: 96% CSF: 96%
Other Notes
Although Total α-Synuclein was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, and canine samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Danger
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
wgk
WGK 3
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B