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Merck
CN

03-0199-00

SMC® Human NPTX2 High Sensitivity Immunoassay Kit

Used for ultrasensitive quantification of Human NPTX2 in human serum, plasma and cerebrospinal fluid (CSF)

别名:

NPTX2 high sensitive immunoassay, NPTX2 single molecule counting kit, Neuronal pentraxin 2 immuno assay kit

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UNSPSC代码:
12161503
NACRES:
NA.84

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产品线

SMC®

用途

 kit sufficient for 96 wells

种属反应性

human

制造商/商品名称

SMC®

assay range

sensitivity: 0.58 pg/mL
(Lower Limit of Quantification)
inter-assay cv: 5%
intra-assay cv: 6%
(five normal plasma samples run in triplicate by 3 different operators on 3 different days)

技术

single molecule counting: suitable

输入

cerebrospinal fluid (CSF)
serum
plasma (K2 EDTA)

UniProt登记号

P47972

相容性

for use with FemtoQuest™ and SMCxPRO® instruments

运输

wet ice

储存温度

2-8°C

相关类别

一般描述

Neuronal Pentraxin 2 (NPTX2) actively contributes to synaptic function and plasticity in the brain. As a member of the pentraxin family, NPTX2 regulates synaptic transmission and clears excess neurotransmitters. Predominantly expressed in neurons, it facilitates the formation and maintenance of synapses, playing a crucial role in learning and memory. NPTX2 has been linked to conditions such as Alzheimer′s disease and schizophrenia. Altered levels of NPTX2 correlate with synaptic dysfunction and cognitive decline, suggesting its potential as a biomarker for these diseases. Additionally, NPTX2 influences neuroinflammatory processes by affecting interactions between neurons and glial cells. Understanding NPTX2′s function and its impact on synaptic integrity and neuroinflammation is essential for developing therapeutic strategies that aim to preserve cognitive function and mitigate the effects of neurodegeneration in various neurological disorders.

应用

NeuroscienceNeurological DisordersNeuronal & Glial Markers

生化/生理作用

Although NPTX2 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, and canine samples, the assay has not been verified for these species.

特点和优势

  • Ultrasensitive Detection: Detects NPTX2 at femtogram per milliliter levels in serum, plasma and CSF.
  • Improved Signal Fidelity: Expanded dynamic range and higher signal-to-noise deliver consistent, accurate results.
  • Familiar Sandwich Format: Uses a standard sandwich immunoassay that ELISA-trained labs can adopt easily while maintaining high sensitivity for Aβ1-42.
  • Automation-compatible Design: Engineered for seamless integration with automated liquid-handling platforms to streamline workflows and reduce manual steps. Dedicated Technical Support: Backed by experts experienced in SMC® assay technology.

包装

96 well assay

分析说明

  • Sensitivity: LLOQ 580 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 290-1,000,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 93% Plasma: 104% CSF: 97%
  • Recovery: Serum: 99% Plasma: 104% CSF: 99%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
NeuroscienceNeurological DisordersNeuronal & Glial Markers

法律信息

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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