03-0199-00
SMC® Human NPTX2 High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Human NPTX2 in human serum, plasma and cerebrospinal fluid (CSF)
别名:
NPTX2 high sensitive immunoassay, Neuronal pentraxin 2 immuno assay kit, NPTX2 single molecule counting kit
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NACRES:
NA.84
UNSPSC Code:
12161503
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments
产品名称
SMC® Human NPTX2 High Sensitivity Immunoassay Kit,
description
Used for ultrasensitive quantification of Human NPTX2 in human serum, plasma and cerebrospinal fluid (CSF)
product line
SMC®
usage
kit sufficient for 96 wells
species reactivity
human
technique(s)
single molecule counting: suitable
input
cerebrospinal fluid (CSF)
serum
plasma (K2 EDTA)
UniProt accession no.
compatibility
for use with FemtoQuest™ and SMCxPRO® instruments
shipped in
wet ice
storage temp.
2-8°C
General description
Neuronal Pentraxin 2 (NPTX2) actively contributes to synaptic function and plasticity in the brain. As a member of the pentraxin family, NPTX2 regulates synaptic transmission and clears excess neurotransmitters. Predominantly expressed in neurons, it facilitates the formation and maintenance of synapses, playing a crucial role in learning and memory. NPTX2 has been linked to conditions such as Alzheimer′s disease and schizophrenia. Altered levels of NPTX2 correlate with synaptic dysfunction and cognitive decline, suggesting its potential as a biomarker for these diseases. Additionally, NPTX2 influences neuroinflammatory processes by affecting interactions between neurons and glial cells. Understanding NPTX2′s function and its impact on synaptic integrity and neuroinflammation is essential for developing therapeutic strategies that aim to preserve cognitive function and mitigate the effects of neurodegeneration in various neurological disorders.
Application
NeuroscienceNeurological DisordersNeuronal & Glial Markers
Features and Benefits
- Ultrasensitive Detection: Detects NPTX2 at femtogram per milliliter levels in serum, plasma and CSF.
- Improved Signal Fidelity: Expanded dynamic range and higher signal-to-noise deliver consistent, accurate results.
- Familiar Sandwich Format: Uses a standard sandwich immunoassay that ELISA-trained labs can adopt easily while maintaining high sensitivity for Aβ1-42.
- Automation-compatible Design: Engineered for seamless integration with automated liquid-handling platforms to streamline workflows and reduce manual steps. Dedicated Technical Support: Backed by experts experienced in SMC® assay technology.
Packaging
96 well assay
Analysis Note
- Sensitivity: LLOQ 580 fg/mL* (SMCxPRO® Instrument)
- Standard Curve Range: 290-1,000,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: Serum: 93% Plasma: 104% CSF: 97%
- Recovery: Serum: 99% Plasma: 104% CSF: 99%
Other Notes
Although NPTX2 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, and canine samples, the assay has not been verified for these species.
Legal Information
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
signalword
Danger
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B