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03-0205-00

SMC® Human TDP-43 Immunoassay Kit

Used for ultrasensitive quantification of Human TDP-43 in human serum, plasma, and cerebrospinal fluid (CSF)

别名:

TDP-43 Single Molecule Counting kit, TDP-43 immunoassay kit, TDP-43 ultra-sensitive immunoassay, Transactive Response DNA-binding Protein 43 immunoassay kit

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关于此项目

UNSPSC Code:
12161503
NACRES:
NA.77
eCl@ss:
32161000
Species reactivity:
human
Technique(s):
single molecule counting: suitable
Usage:
 kit sufficient for 96 wells
Compatibility:
for use with FemtoQuest™ and SMCxPRO® instruments
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产品名称

SMC® Human TDP-43 Immunoassay Kit,

Quality Segment

200

description

Used for ultrasensitive quantification of Human TDP-43 in human serum, plasma, and cerebrospinal fluid (CSF)

product line

SMC®

usage

 kit sufficient for 96 wells

species reactivity

human

parameter

100 μL sample volume (CSF), 12.5 μL sample volume (serum and plasma)

technique(s)

single molecule counting: suitable

input

serum
plasma (K2 EDTA)
cerebrospinal fluid (CSF)
cerebrospinal fluid (CSF)
plasma

UniProt accession no.

Q13148

compatibility

for use with FemtoQuest™ and SMCxPRO® instruments

shipped in

wet ice

storage temp.

2-8°C

General description

TAR DNA-binding protein 43 (TDP-43) plays a crucial role in regulating gene expression, RNA processing, and the transport of RNA within neurons. It is involved in maintaining neuronal health by facilitating the splicing of pre-mRNA and ensuring the stability of mRNA, which is essential for proper protein synthesis. When TDP-43 mislocalizes from the nucleus to the cytoplasm, it forms toxic aggregates that disrupt cellular function and contribute to neuronal degeneration. TDP-43 has become associated with conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as its abnormal accumulation often correlates with disease severity and progression. Investigation into the role of TDP-43 in neuroinflammation and neurodegeneration can help identify potential therapeutic targets that counteract its harmful effects on neuronal health and function in various neurodegenerative disorders.

Application

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neurofilament & Neuron Metabolism / Neuronal & Glial Markers / Neurodegenerative Medicine / Neuroscience

Features and Benefits

  • Ultra-Sensitive Measurement: Detects TDP-43 down to fg/mL levels in serum, plasma and CSF.
  • Reliable Data: Enhanced dynamic range with improved signal-to-noise ratio ensures accurate and dependable results.
  • Easy to Adopt: Familiar sandwich immunoassay format allows researchers with ELISA experience to quickly adopt the technology into their workflow.
  • Automated Workflow: Compatible with automated liquid handling systems, to reduce manual steps and boosts laboratory productivity.
  • Expert Support: Technical assistance is provided by specialized field scientists and technical teams.

Packaging

96 well assay

Analysis Note

  • Sensitivity: LLOQ 5,210 fg/mL* (SMCxPRO® Instrument)
  • Standard Curve Range: 2,600-6,000,000 fg/mL
  • Intra-assay CV: <15%
  • Inter-assay CV: <20%
  • Linearity: Serum: 105% Plasma 103% CSF: 103%
  • Recovery: Serum: 96% Plasma: 100% CSF: 89%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

Other Notes

Although TDP-43 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, and canine samples, the assay has not been verified for these species.

Legal Information

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

flash_point_f

Not applicable

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - ED ENV 1 - Eye Irrit. 2 - Repr. 1B

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

flash_point_c

Not applicable

wgk

WGK 3

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